Abstract

The imaging core will provide the following services for COBRE investigators: Laser Scanning Confocal Microscopy, with capability for microinjection and micro-manipulation, sophisticated image analysis programs with a dedicated computer workstation; transmission electron microscopy to be used for confirming cellular apoptosis; laser capture microdissection for isolating normal and cancer cells from histological specimens. This core will provide investigator/technician training if desired for individual laboratory use of the instruments. Alternatively, the core will provide complete specimen analysis using its own personnel. COBRE members will have priority in use of these imaging services when demand is high from other members of the University community. Also, COBRE members will receive a 50% offset from customary charges. The core Director and appropriate technical personnel will work with COBRE investigators in experimental design and specimen preparation so that high quality data will be obtained.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
1P20RR020180-01
Application #
6973104
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2004-09-23
Project End
2005-07-31
Budget Start
2004-09-23
Budget End
2005-07-31
Support Year
1
Fiscal Year
2004
Total Cost
$188,278
Indirect Cost

  Institution

Name
Marshall University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
036156615
City
Huntington
State
WV
Country
United States
Zip Code
25701

  Publications

Abbas, Ata; Hall, J Adam; Patterson 3rd, William L et al. (2016) Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. Biochem Cell Biol 94:71-81
Silvis, Anne M; McCormick, Michael L; Spitz, Douglas R et al. (2016) Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid. Redox Biol 7:88-96
Valentovic, Monica A; Ball, John G; Brown, J Mike et al. (2014) Resveratrol attenuates cisplatin renal cortical cytotoxicity by modifying oxidative stress. Toxicol In Vitro 28:248-57
Mathis, Sarah E; Alberico, Anthony; Nande, Rounak et al. (2014) Chemo-predictive assay for targeting cancer stem-like cells in patients affected by brain tumors. PLoS One 9:e105710
Hardman, W Elaine (2014) Walnuts have potential for cancer prevention and treatment in mice. J Nutr 144:555S-560S
Hardman, W Elaine (2014) Diet components can suppress inflammation and reduce cancer risk. Nutr Res Pract 8:233-40
Abbas, Ata; Patterson 3rd, William; Georgel, Philippe T (2013) The epigenetic potentials of dietary polyphenols in prostate cancer management. Biochem Cell Biol 91:361-8
Fahrmann, Johannes F; Ballester, Oscar F; Ballester, Gabriela et al. (2013) Inhibition of nuclear factor kappa B activation in early-stage chronic lymphocytic leukemia by omega-3 fatty acids. Cancer Invest 31:24-38
Aimola, Pierpaolo; Carmignani, Marco; Volpe, Anna Rita et al. (2012) Cadmium induces p53-dependent apoptosis in human prostate epithelial cells. PLoS One 7:e33647
Nande, Rounak; Di Benedetto, Altomare; Aimola, Pierpaolo et al. (2012) Targeting a newly established spontaneous feline fibrosarcoma cell line by gene transfer. PLoS One 7:e37743

Showing the most recent 10 out of 47 publications