This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed modeling will focus on the control, acquisition, and re-acquisition after brain injury (such as strokes) of coordinated control programs for the visual and proprioceptive control of coordinated arm and hand movements (Jeannerod et al., 1995). This work will allow us a) to make specific and testable predictions on the organization and the reorganization after brain injury of the arm and hand motor circuits, and b) to propose new directions for the development of effective rehabilitation programs. Part 1: Modeling interactions between cortex, basal ganglia (BG), and neuromodulators in acquisition, control and re-acquisition after brain injury, of coordinated arm and hand movements. Part 2. Extension of the computational model from rats to humans to explore the role of observation in motor training - predictions on 'rehabilitation via observation'.
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