This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives: The major aims of the Chemistry Core of the Center of Research Excellence in Natural Products Neuroscience are to isolate, characterize and optimize the active principles of plants, bacteria, fungi, and marine organisms with potential nervous system activity. This core will be responsible for the elucidation of structures and provide material for in vitro and in vivo pharmacological studies in order to develop new psychotropic drug candidates and research tools to study nervous system function. The Chemistry Core will also have an advisory role for individual projects that require expertise in the isolation, structure elucidation and lead optimization of natural products based drug leads and prototypes. The expertise of the Chemistry Core includes: (a) isolation and purification of active secondary metabolites on a mg to kg scale, (b) structure elucidation of isolated active principles, (c) re-isolation or synthesis of larger quantities of active components for in vitro and in vivo studies, and (d) semi-synthetic modification of lead compounds to generate SAR data and to further develop drug candidates.
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