This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The objective of this proposed study is to investigate small molecule natural product-derived hypoxia-inducible factor-1 (HIF-1) inhibitors as potential molecular-targeted agents for the treatment of neuroblastoma, the most common pediatric solid tumor predominantly found in early childhood.
The Specific Aims are: 1) to determine the effects of natural product-derived HIF-1 inhibitors on hypoxia-induced dedifferentiation in neuroblastoma cells; and 2) to evaluate the potential of natural product-derived HIF-1 inhibitors to overcome hypoxia-induced resistance to chemotherapeutic agents.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR021929-03
Application #
7720414
Study Section
Special Emphasis Panel (ZRR1-RI-8 (02))
Project Start
2008-07-01
Project End
2009-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
3
Fiscal Year
2008
Total Cost
$137,932
Indirect Cost
Name
University of Mississippi
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
067713560
City
University
State
MS
Country
United States
Zip Code
38677
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