Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The initial aims of the current project were to evaluate the temporal and spatial integrity (i.e., connectivity) of the auditory attention network in patients with schizophrenia (SP) and healthy controls (HC) by studying the electromagnetic (magnetoencephalogram;MEG) and hemodynamic (functional magnetic resonance imaging;FMRI) response to basic auditory stimuli. To different paradigms were utilized. The first paradigm examined passive attentional responses to pairs of identical and non-identical tones, as well single tones (FMRI only). The second paradigm examined how patients and controls actively allocate attentional resources to extrapersonal space based on auditory cues and targets (FMRI and MEG). In addition, we also proposed to examine the relationship between imaging markers of basic auditory attention, clinical performance on cognitive testing and single nucleotide polymorphisms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR021938-04
Application #
8360222
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
4
Fiscal Year
2011
Total Cost
$248,842
Indirect Cost

  Institution

Name
The Mind Research Network
Department
Type
DUNS #
098640696
City
Albuquerque
State
NM
Country
United States
Zip Code
87106

  Publications

Edgar, J C; Fisk 4th, Charles L; Chen, Yu-Han et al. (2018) Identifying auditory cortex encoding abnormalities in schizophrenia: The utility of low-frequency versus 40 Hz steady-state measures. Psychophysiology 55:e13074
Thoma, Robert J; Haghani Tehrani, Poone; Turner, Jessica A et al. (2018) Neuropsychological analysis of auditory verbal hallucinations. Schizophr Res 192:459-460
Sanfratello, Lori; Aine, Cheryl; Stephen, Julia (2018) Neuroimaging investigations of dorsal stream processing and effects of stimulus synchrony in schizophrenia. Psychiatry Res Neuroimaging :
Wu, Lei; Caprihan, Arvind; Bustillo, Juan et al. (2018) An approach to directly link ICA and seed-based functional connectivity: Application to schizophrenia. Neuroimage 179:448-470
Mennigen, Eva; Miller, Robyn L; Rashid, Barnaly et al. (2018) Reduced higher-dimensional resting state fMRI dynamism in clinical high-risk individuals for schizophrenia identified by meta-state analysis. Schizophr Res 201:217-223
Kong, Xiang-Zhen; Mathias, Samuel R; Guadalupe, Tulio et al. (2018) Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A 115:E5154-E5163
Faghiri, Ashkan; Stephen, Julia M; Wang, Yu-Ping et al. (2018) Changing brain connectivity dynamics: From early childhood to adulthood. Hum Brain Mapp 39:1108-1117
Orban, Pierre; Dansereau, Christian; Desbois, Laurence et al. (2018) Multisite generalizability of schizophrenia diagnosis classification based on functional brain connectivity. Schizophr Res 192:167-171
Du, Yuhui; Fu, Zening; Calhoun, Vince D (2018) Classification and Prediction of Brain Disorders Using Functional Connectivity: Promising but Challenging. Front Neurosci 12:525
Trapp, Cameron; Vakamudi, Kishore; Posse, Stefan (2018) On the detection of high frequency correlations in resting state fMRI. Neuroimage 164:202-213

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