The primary goal of this COBRE proposal is to increase the number of NIH-supported biomedical researchers in the state of South Carolina, particularly at Clemson University (CU). For this purpose, CU's unique strengths in biomaterials and tissue engineering will be complemented by expertise in medicine and developmental biology at the Medical University of South Carolina (MUSC) and the University of South Carolina (USC) to establish a Center of Biomaterials for Tissue Regeneration (CBTR) at CU. To accomplish the center's goal, an outstanding cadre of mentors will mentor junior investigators toward independence as NIH-supported investigators. The center's tissue-regeneration theme simultaneously fits South Carolina's strength in regenerative medicine while addressing a significant cause of mortality and morbidity worldwide: End-stage organ failure and tissue loss create healthcare costs of nearly $400 billion annually in the US alone. Research in tissue regeneration offers the possibility of relief for these human and economic costs through restoration of functional tissues. The scientific focus of this center will be regulation of tissue regeneration through cell biomaterials interactions. Four projects from junior investigators have been rigorously selected to fit this theme. These projects are 1) Stem cell-myocyte electrical coupling via a laser-patterned cell bridge;2) Biomaterials for guided neural regeneration;3) BMP-4 as a novel angiogenic factor and its potential use in tissue engineering;and 4) Endothelial response-guided design of hyaluronan-based vascular grafts. These target investigators will be paired with mentors who are established, NIH-supported researchers with excellent track records in mentoring and with surgeons who will keep projects clinically relevant. The projects will be supported by a well-organized infrastructure and three state-of-the-art core facilities (Materials Synthesis, Characterization and Testing, Histology and Imaging, and Cell and Molecular Engineering). We have unprecedented state and institutional support to establish this center. CU will recruit three junior investigators to expand activities of this center. The state of South Carolina has also approved $2M at each institution (CU, MUSC, and USC) to support endowed chairs in regenerative medicine;the endowments have been matched by each institution to yield a total of $12M. Our nationally recognized External Advisory Committee members will critically evaluate the center's progress. This COBRE will significantly augment collaborative efforts in South Carolina to recruit, train, and retain a critical mass of investigators with cross-disciplinary skills to collaborate effectively in the research area of regenerative medicine.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR021949-03
Application #
8092545
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Canto, Maria Teresa
Project Start
2009-09-30
Project End
2014-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
3
Fiscal Year
2011
Total Cost
$1,908,323
Indirect Cost
Name
Clemson University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
042629816
City
Clemson
State
SC
Country
United States
Zip Code
29634
Altamirano, Sophie; Simmons, Charles; Kozubowski, Lukasz (2018) Colony and Single Cell Level Analysis of the Heterogeneous Response of Cryptococcus neoformans to Fluconazole. Front Cell Infect Microbiol 8:203
Karousou, Evgenia; Misra, Suniti; Ghatak, Shibnath et al. (2017) Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol 59:3-22
Zhang, Jeremy; Sen, Atanu; Cho, Eunhee et al. (2017) Poloxamine/fibrin hybrid hydrogels for non-viral gene delivery. J Tissue Eng Regen Med 11:246-255
Liu, Honghai; Qin, Wan; Wang, Zhonghai et al. (2016) Disassembly of myofibrils and potential imbalanced forces on Z-discs in cultured adult cardiomyocytes. Cytoskeleton (Hoboken) 73:246-57
Huang, Ting; Wang, Zhonghai; Wei, Lina et al. (2016) Microelectrode Array-evaluation of Neurotoxic Effects of Magnesium as an Implantable Biomaterial. J Mater Sci Technol 32:89-96
Kuang, Serena Y; Yang, Xiaoqi; Wang, Zhonghai et al. (2016) How Microelectrode Array-Based Chick Forebrain Neuron Biosensors Respond to Glutamate NMDA Receptor Antagonist AP5 and GABAA Receptor Antagonist Musimol. Sens Biosensing Res 10:9-14
Levine, Robert A; Hag├ęge, Albert A; Judge, Daniel P et al. (2015) Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol 12:689-710
Kuang, Serena Y; Wang, Zhonghai; Huang, Ting et al. (2015) Prolonging life in chick forebrain-neuron culture and acquiring spontaneous spiking activity on a microelectrode array. Biotechnol Lett 37:499-509
Nahar-Gohad, Pranjal; Gohad, Neeraj; Tsai, Chen-Chih et al. (2015) Rat aortic smooth muscle cells cultured on hydroxyapatite differentiate into osteoblast-like cells via BMP-2-SMAD-5 pathway. Calcif Tissue Int 96:359-69
Olsen, T R; Mattix, B; Casco, M et al. (2015) Manipulation of cellular spheroid composition and the effects on vascular tissue fusion. Acta Biomater 13:188-98

Showing the most recent 10 out of 107 publications