Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The work in the project is to develop an understanding of the origins of congenital vascular malformations. These efforts are specifically looking at the genetic basis of Klippel Trenaunay Syndrome, and the role of the gene VG5Q in this disease. Animal models are being developed to understand the functions of this factor, as well as to develop a model of this disease. The expections of this project are to understand, at a molecular level, how this gene product functions and how it interferes with normal development of the fetal vasculature.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR024214-03
Application #
7959575
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2009-07-01
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
3
Fiscal Year
2009
Total Cost
$220,028
Indirect Cost

  Institution

Name
University of Kansas
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Pohler, Ky G; Green, Jonathan A; Moley, Laura A et al. (2017) Circulating microRNA as candidates for early embryonic viability in cattle. Mol Reprod Dev 84:731-743
Rogers, Robert S; Tungtur, Sudheer; Tanaka, Tomohiro et al. (2017) Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice. Front Neurosci 11:473
Navakanitworakul, Raphatphorn; Hung, Wei-Ting; Gunewardena, Sumedha et al. (2016) Characterization and Small RNA Content of Extracellular Vesicles in Follicular Fluid of Developing Bovine Antral Follicles. Sci Rep 6:25486
Aleksandrova, Anastasiia; Czirok, Andras; Kosa, Edina et al. (2015) The endoderm and myocardium join forces to drive early heart tube assembly. Dev Biol 404:40-54
Nishimune, Hiroshi; Stanford, John A; Mori, Yasuo (2014) Role of exercise in maintaining the integrity of the neuromuscular junction. Muscle Nerve 49:315-24
Wang, Huizhen; Larson, Melissa; Jablonka-Shariff, Albina et al. (2014) Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice. Proc Natl Acad Sci U S A 111:5735-40
Zhang, Yu-Kun Jennifer; Lu, Hong; Klaassen, Curtis D (2013) Expression of human CAR splicing variants in BAC-transgenic mice. Toxicol Sci 132:142-50
Elsarraj, Hanan S; Hong, Yan; Valdez, Kelli et al. (2013) A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance. J Cell Sci 126:2446-58
Galvin-Burgess, Katherine E; Travis, Emily D; Pierson, Kelsey E et al. (2013) TGF-?-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium. Stem Cells 31:48-58
Nishimune, Hiroshi (2012) Active zones of mammalian neuromuscular junctions: formation, density, and aging. Ann N Y Acad Sci 1274:24-32

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