Abstract

The neuropathology core will establish and implement procedures for a uniform, detailed neuropathologic evaluation of postmortem tissues of all Alzheimer's Disease Research Center patients who come to autopsy. Procedures to obtain central nervous system materials suitable for biochemical and related studies in patients who have a rapid autopsy (up to four to six hours interval between death and autopsy) will be established as well. A computerized data base compatible with CERAD protocols will be established and implemented. Neuropathology will support Projects 1, 3, and 4 in particular and all ADRC activities in general with correlations of neuropathology, neuroimaging and clinical data obtained from all ADRC sources.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG008031-03
Application #
3790300
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Jack Jr, C R; O'Brien, P C; Rettman, D W et al. (2001) FLAIR histogram segmentation for measurement of leukoaraiosis volume. J Magn Reson Imaging 14:668-76
Jack Jr, C R; Petersen, R C; Xu, Y et al. (2000) Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology 55:484-89
Jack Jr, C R; Petersen, R C; Xu, Y C et al. (1999) Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 52:1397-403
Leibson, C; Owens, T; O'Brien, P et al. (1999) Use of physician and acute care services by persons with and without Alzheimer's disease: a population-based comparison. J Am Geriatr Soc 47:864-9
Jack Jr, C R; Petersen, R C; Xu, Y et al. (1998) Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology 51:993-9
Lucas, J A; Ivnik, R J; Smith, G E et al. (1998) Mayo's older Americans normative studies: category fluency norms. J Clin Exp Neuropsychol 20:194-200
Lucas, J A; Ivnik, R J; Smith, G E et al. (1998) Normative data for the Mattis Dementia Rating Scale. J Clin Exp Neuropsychol 20:536-47
Petersen, R C (1998) Clinical subtypes of Alzheimer's disease. Dement Geriatr Cogn Disord 9 Suppl 3:16-24
Jack Jr, C R; Petersen, R C; Xu, Y C et al. (1998) Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol 43:303-10
Ivnik, R J; Smith, G E; Lucas, J A et al. (1997) Free and cued selective reminding test: MOANS norms. J Clin Exp Neuropsychol 19:676-91

Showing the most recent 10 out of 22 publications