Abstract

The Neuropathology Core is central tot he efforts of the ADCC. In the core the brains from patients, identified as probable AD and studied in vivo by the Clinical Core, are examined neuropathologically to provide a definitive diagnosis of the causes(s) of the clinical syndrome. Brains of similarly identified and studied normal elderly controls are also examined for comparison purposes. The core includes a Morphometry Component at IBR which provides quantitative neuropathologic data for correlation with antemortem clinical neuroimaging information. The core also serves as the central clearing house for the storage and distribution of tissue in appropriate states (fixed, fresh, frozen) to research laboratories in the center. Finally, the core collaborates with other cores and projects of the center, supplying neuroanatomical as well as neuropathological expertise and contributing to the overall centralized database of the center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG008051-09
Application #
6267417
Study Section
Project Start
1998-07-01
Project End
1999-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Wenning, Gregor; Trojanowski, John Q; Kaufmann, Horacio et al. (2018) Is multiple system atrophy an infectious disease? Ann Neurol 83:10-12
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Ahuja, Shilpi; Chen, Rebecca K; Kam, Korey et al. (2018) Role of normal sleep and sleep apnea in human memory processing. Nat Sci Sleep 10:255-269
Zhou, Hao Henry; Singh, Vikas; Johnson, Sterling C et al. (2018) Statistical tests and identifiability conditions for pooling and analyzing multisite datasets. Proc Natl Acad Sci U S A 115:1481-1486
Sharma, Ram A; Varga, Andrew W; Bubu, Omonigho M et al. (2018) Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study. Am J Respir Crit Care Med 197:933-943
Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Tolea, Magdalena I; Chrisphonte, Stephanie; Galvin, James E (2018) Sarcopenic obesity and cognitive performance. Clin Interv Aging 13:1111-1119
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021

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