The objective of the neuroimaging Core is to provide support for the clinical and neuropathology cores of the ADCC, for funded MR and PET projects and to promote new research opportunities. The core creates and maintains multiple databases across projects, imaging modalities, technical support functions and routine clinical needs. The neuroimaging core which has been in operation for one year has implemented a uniform and rapidly acquired high resolution MR protocol. In the pst year in collaboration with the clinical core over 200 MR studies were completed and normal aging MR data base was created. The core provides userfriendly procedures for reading, archiving, reformatting, region of interest work and maintaining the hardware environment. moreover, the new core has and is continuing to develop, test and implement several innovative and important anatomic tools. The ongoing work includes new MR sequences for tissue segmentation, multimodal coregistration of 3-D images sets, improved reformatting of high resolution MR data with stereotactic image marking, 3-D surface rendering and functional MR imaging. Many new clinical, neuropathology and technical projects have been initiated. A main research goal supported by the core has been to identify and validate in cognitively normal elderly, ante-mortem markers for AD. In recent years we have developed a line of investigation that has led to a predictive neuroimaging test for the development of AD. In the past year this work has resulted in the completion of several volumetric studies of normal aging and nondemented elderly at risk for the development of AD. These studies demonstrated within the temporal lobe, the existence of an anatomic specificity for hippocampal volume loss that is uniquely related to recent memory changes in both normal aging and in at risk patients. Current studies utilizing the core are now examining the specificity hypothesis across imaging modalities with respect ot other candidate brain regions. The core has continued its long established tradition of training new investigators and this is now extended to several other institutional settings. These collaborative efforts alone with the rich clinical environment of the ADCC provide access to different populations of patients and the sharing of new research strategies.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
New York
United States
Zip Code
Zhou, Hao Henry; Singh, Vikas; Johnson, Sterling C et al. (2018) Statistical tests and identifiability conditions for pooling and analyzing multisite datasets. Proc Natl Acad Sci U S A 115:1481-1486
Sharma, Ram A; Varga, Andrew W; Bubu, Omonigho M et al. (2018) Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study. Am J Respir Crit Care Med 197:933-943
Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Tolea, Magdalena I; Chrisphonte, Stephanie; Galvin, James E (2018) Sarcopenic obesity and cognitive performance. Clin Interv Aging 13:1111-1119
Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Kochunov, Peter; Dickie, Erin W; Viviano, Joseph D et al. (2018) Integration of routine QA data into mega-analysis may improve quality and sensitivity of multisite diffusion tensor imaging studies. Hum Brain Mapp 39:1015-1023
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307

Showing the most recent 10 out of 604 publications