Abstract

The Neuropathology Core is central tot he efforts of the ADCC. In the core the brains from patients, identified as probable AD and studied in vivo by the Clinical Core, are examined neuropathologically to provide a definitive diagnosis of the causes(s) of the clinical syndrome. Brains of similarly identified and studied normal elderly controls are also examined for comparison purposes. The core includes a Morphometry Component at IBR which provides quantitative neuropathologic data for correlation with antemortem clinical neuroimaging information. The core also serves as the central clearing house for the storage and distribution of tissue in appropriate states (fixed, fresh, frozen) to research laboratories in the center. Finally, the core collaborates with other cores and projects of the center, supplying neuroanatomical as well as neuropathological expertise and contributing to the overall centralized database of the center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG008051-10S2
Application #
6218707
Study Section
Project Start
1999-08-15
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Chen, Jingyun; Li, Yi; Pirraglia, Elizabeth et al. (2018) Quantitative evaluation of tau PET tracers 18F-THK5351 and 18F-AV-1451 in Alzheimer's disease with standardized uptake value peak-alignment (SUVP) normalization. Eur J Nucl Med Mol Imaging 45:1596-1604
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
de Leon, Mony J; Li, Yi; Rusinek, Henry (2018) Reply: Cerebrospinal Fluid, Hyposmia, and Dementia in Alzheimer Disease: Insights from Dynamic PET and a Hypothesis. J Nucl Med 59:718-719
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
de Leon, Mony J; Pirraglia, Elizabeth; Osorio, Ricardo S et al. (2018) The nonlinear relationship between cerebrospinal fluid A?42 and tau in preclinical Alzheimer's disease. PLoS One 13:e0191240
Lakshmanan, Karthik; Brown, Ryan; Madelin, Guillaume et al. (2018) An eight-channel sodium/proton coil for brain MRI at 3 T. NMR Biomed 31:
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Herline, Krystal; Prelli, Frances; Mehta, Pankaj et al. (2018) Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model. Alzheimers Res Ther 10:54

Showing the most recent 10 out of 604 publications