The Alzheimers Disease Center (ADC) at New York University School of Medicine is structured as an Alzheimers Disease Core Center (ADCC). It provides core resources and pilot study support to a comprehensive multi-disciplinary research program on Alzheimers Disease (AD). Investigators at the NYS Institute for Basic Research (IBR), the Bellevue Hospital Center (BHC), the Nathan Kline Institute (NKI) and other New York City area facilities are also participating. The ADCC encompasses physical, patient and laboratory resources, relevant research projects and pilot studies and an established group of investigators committed to studying AD. The general goal of the Center is to integrate, expand and facilitate innovative basic and clinical research to extend knowledge about the pathophysiology, early diagnosis and treatments of AD. Patients with AD and related disorders, subjects with mild cognitive impairment and normal elderly subjects are studied longitudinally through postmortem. AD research served by the ADCC include molecular and cellular biology; neuropathologic-clinical correlation; in vivo neuroimaging; clinical symptomatology and longitudinal course; cognition and psychopharmacology; and AD caregiver studies. The ADCC is supervised by a Director and seven Associate leaders who serve on an Executive Committee, an Institutional Steering Committee and an External Scientific Advisory Committee. Cores support consist of Administrative, Clinical (including CSF and Serum/DNA Banks, and a Satellite Diagnostic and Treatment Center [SDTC] focusing on minority recruitment at BHC), Neuroimaging, Neuropathology (including a morphometry component at IBR, and a proposed new satellite at Sun Health Research Institute [SunCity, Az]), Data Management, Caregiver and Education and Information Transfer. Each year, three pilot studies are directly supported by the ADCC. In addition, extensive current research receiving primary support from other sources is facilitated by ADCC core facilities through utilization of core resources. During the current funding period, the core resources have been maintained and the base of AD research at NYU has been expanded, in part through recruitment of established investigators. The new Caregiver core has been added to the Center, and there are increased collaborations with other ADCs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG008051-11S1
Application #
6334224
Study Section
Special Emphasis Panel (ZAG1 (J1))
Program Officer
Phelps, Creighton H
Project Start
1990-08-20
Project End
2005-04-30
Budget Start
2000-08-15
Budget End
2001-04-30
Support Year
11
Fiscal Year
2000
Total Cost
$48,107
Indirect Cost
Name
New York University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Drummond, Eleanor; Nayak, Shruti; Pires, Geoffrey et al. (2018) Isolation of Amyloid Plaques and Neurofibrillary Tangles from Archived Alzheimer's Disease Tissue Using Laser-Capture Microdissection for Downstream Proteomics. Methods Mol Biol 1723:319-334
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Chen, Jingyun; Li, Yi; Pirraglia, Elizabeth et al. (2018) Quantitative evaluation of tau PET tracers 18F-THK5351 and 18F-AV-1451 in Alzheimer's disease with standardized uptake value peak-alignment (SUVP) normalization. Eur J Nucl Med Mol Imaging 45:1596-1604
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
de Leon, Mony J; Li, Yi; Rusinek, Henry (2018) Reply: Cerebrospinal Fluid, Hyposmia, and Dementia in Alzheimer Disease: Insights from Dynamic PET and a Hypothesis. J Nucl Med 59:718-719
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
de Leon, Mony J; Pirraglia, Elizabeth; Osorio, Ricardo S et al. (2018) The nonlinear relationship between cerebrospinal fluid A?42 and tau in preclinical Alzheimer's disease. PLoS One 13:e0191240
Lakshmanan, Karthik; Brown, Ryan; Madelin, Guillaume et al. (2018) An eight-channel sodium/proton coil for brain MRI at 3 T. NMR Biomed 31:
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169

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