The Clinical Core has been reorganized in order to broaden its mission, namely, to create a vigorous multidisciplinary clinical program in order to promote research in dementia. The Clinical Core will provide excellent clinical evaluation, treatment, and collaborative management of all patients and controls, as well as documentation of these activities. It will fulfill this mission through achieving 11 aims: 1) integrate and coordinate existing clinical resources; 2) establish and maintain evaluation and documentation standards; 3) create and maintain a registry; 4) broaden the demographic characteristics of subjects enrolled; 5) create, maintain, and use a high quality analyzable database; 6) design and support new clinical initiatives; 7) assist in development and implementation of multi-center studies; 8) enroll patients wand controls in post-mortem studies; 9) enroll patients and controls in clinical studies; 10) meet regularly with faculty of the neuropathology Core; 11) provide a clinical education resource for trainees. In these ways the Core will enhance current research activities, foster current strengths, and assist in the development of new research areas to complement existing strengths.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG008665-10S4
Application #
6397799
Study Section
Project Start
1999-06-01
Project End
2003-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
2000
Total Cost
$326,136
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Chapman, Robert M; Gardner, Margaret N; Mapstone, Mark et al. (2015) Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage. Brain Res 1604:74-83
Chapman, Robert M; Porsteinsson, Anton P; Gardner, Margaret N et al. (2013) C145 as a short-latency electrophysiological index of cognitive compensation in Alzheimer's disease. J Alzheimers Dis 33:55-68
Chapman, Robert M; Mapstone, Mark; Gardner, Margaret N et al. (2011) Women have farther to fall: gender differences between normal elderly and Alzheimer's disease in verbal memory engender better detection of Alzheimer's disease in women. J Int Neuropsychol Soc 17:654-62
Chapman, Robert M; Mapstone, Mark; McCrary, John W et al. (2011) Predicting conversion from mild cognitive impairment to Alzheimer's disease using neuropsychological tests and multivariate methods. J Clin Exp Neuropsychol 33:187-99
Chapman, Robert M; McCrary, John W; Gardner, Margaret N et al. (2011) Brain ERP components predict which individuals progress to Alzheimer's disease and which do not. Neurobiol Aging 32:1742-55
Chapman, Robert M; Mapstone, Mark; Porsteinsson, Anton P et al. (2010) Diagnosis of Alzheimer's disease using neuropsychological testing improved by multivariate analyses. J Clin Exp Neuropsychol 32:793-808
Price, Joseph L; McKeel Jr, Daniel W; Buckles, Virginia D et al. (2009) Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging 30:1026-36
Chapman, Robert M; Nowlis, Geoffrey H; McCrary, John W et al. (2007) Brain event-related potentials: diagnosing early-stage Alzheimer's disease. Neurobiol Aging 28:194-201
Hurley, Sean D; Coleman, Paul D (2003) Facial nerve axotomy in aged and young adult rats: analysis of the glial response. Neurobiol Aging 24:511-8
Porsteinsson, Anton P; Tariot, Pierre N; Jakimovich, Laura J et al. (2003) Valproate therapy for agitation in dementia: open-label extension of a double-blind trial. Am J Geriatr Psychiatry 11:434-40

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