The Neuropathology (NP) Core of the UCLA-Alzheimer's disease Center (ADC) has accomplished its original goals and formulated new and continuing specific aims for this proposal. Over 100 brains have been accessioned to the UCLA ADC bank. In the renewal phase, the NP will perform complete or 'brain only' autopsies on patients enlisted in the Autopsy Program, and will serve as a data and tissue/fluid resource for individuals performing innovative research on AD/SDAT, non-AD, dementias, and a broader spectrum of scientists interested in neurodegenerative conditions. Brain tissues from appropriate autopsies will be triaged at the time of necropsy in order to optimize their subsequent use for structural and molecular/pharmacologic research. The tissue harvesting method will be one developed over the initial grant funding period, i.e. materials will be stored frozen, paraformaldehyde fixed, or in paraffin blocks. Tissue studies in the NP Core will include systematic blocking of fixed brain tissue, routine and specialized silver stains that demonstrate microscopic AD-related lesions (seline plaques and neurofibrillary tangles), and immunohistochemical staining using both commercially available antibodies and reagents developed in the NP Core or with collaborating investigators. Thus tissues/fluids provided to investigators will have been carefully assessed for AD and related disease processes. Other functions of the NP Core will include (a) interactions with the Clinical and Imaging Cores to examine correlative data, (b) morphologic/immunohistochemical support of ongoing AD-related studies by direct collaboration or provision of key reagents, ~ liaison with community pathologists who are called upon to assess brain tissue from dementia patients, (d) discussion with lay groups of the importance of autopsies on demented patients, and (e) assessing ApoE genotypes in ADC patients.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Burggren, Alison C; Mahmood, Zanjbeel; Harrison, Theresa M et al. (2017) Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ?4 variant. Alzheimers Dement 13:739-748
Clark, David Glenn; McLaughlin, Paula M; Woo, Ellen et al. (2016) Novel verbal fluency scores and structural brain imaging for prediction of cognitive outcome in mild cognitive impairment. Alzheimers Dement (Amst) 2:113-22
Merrill, David A; Siddarth, Prabha; Raji, Cyrus A et al. (2016) Modifiable Risk Factors and Brain Positron Emission Tomography Measures of Amyloid and Tau in Nondemented Adults with Memory Complaints. Am J Geriatr Psychiatry 24:729-37
Baerresen, Kimberly M; Miller, Karen J; Hanson, Eric R et al. (2015) Neuropsychological tests for predicting cognitive decline in older adults. Neurodegener Dis Manag 5:191-201
Chen, Stephen T; Siddarth, Prabha; Saito, Nathan Y et al. (2014) Psychological well-being and regional brain amyloid and tau in mild cognitive impairment. Am J Geriatr Psychiatry 22:362-9
Burggren, Alison; Brown, Jesse (2014) Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease. Brain Imaging Behav 8:251-61
Donix, Markus; Burggren, Alison C; Scharf, Maria et al. (2013) APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease. Psychiatry Res 214:212-20
Merrill, David A; Siddarth, Prabha; Kepe, Vladimir et al. (2013) Vascular risk and FDDNP-PET influence cognitive performance. J Alzheimers Dis 35:147-57
Protas, Hillary D; Kepe, Vladimir; Hayashi, Kiralee M et al. (2012) Prediction of cognitive decline based on hemispheric cortical surface maps of FDDNP PET. Neuroimage 61:749-60
Merrill, David A; Siddarth, Prabha; Saito, Nathan Y et al. (2012) Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia. Int Psychogeriatr 24:1076-84

Showing the most recent 10 out of 213 publications