The Neuropathology Core will coordinate post-mortem retrieval of brains from patients studied in the Clinical Core and will dissect and preserve these brains in an anatomically precise manner. This will permit application of multiple immunocytochemical, molecular biological and biochemical procedures to specific brain regions that also have been subjected to semi-quantitative histologic assessment of Alzheimer's disease abnormalities (senile plaques, neurofibrillary tangles, neuronal loss, abnormal neurites) using silver, tinctorial and immunostaining; measurement of senile plaque; differential counts of plaques by type; and biochemical assay of choline acetyltransferase and Alzheimer-related proteins. The results of the neuropathologic and biochemical assessments will be compared with each other and with clinical/neuroimaging assessments in order to assess diagnostic accuracy and identify neuropathologic indices of disease severity and localication that correlate with cognitive defects. These comparisons will test the accuracy of the assessments and provide to collaborating scientists large amounts of well studied brain tissue with a known type and degree of pathology.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010129-03
Application #
3768471
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Jena, Prasant Kumar; Sheng, Lili; Di Lucente, Jacopo et al. (2018) Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. FASEB J 32:2866-2877
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Maezawa, Izumi; Nguyen, Hai M; Di Lucente, Jacopo et al. (2018) Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain 141:596-612
Meyer, Oanh L; Liu, Xiaoyan Lucia; Tancredi, Daniel et al. (2018) Acculturation level and caregiver outcomes from a randomized intervention trial to enhance caregivers' health: evidence from REACH II. Aging Ment Health 22:730-737
Fletcher, Evan; Gavett, Brandon; Harvey, Danielle et al. (2018) Brain volume change and cognitive trajectories in aging. Neuropsychology 32:436-449
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Dadar, Mahsa; Maranzano, Josefina; Ducharme, Simon et al. (2018) Validation of T1w-based segmentations of white matter hyperintensity volumes in large-scale datasets of aging. Hum Brain Mapp 39:1093-1107
Wong, Jonathan M; Gray, John A (2018) Long-Term Depression Is Independent of GluN2 Subunit Composition. J Neurosci 38:4462-4470

Showing the most recent 10 out of 1156 publications