Abstract

The UCD ADC added a formal biostatistics component to its successful data management program at the time of renewal in 2001, reflecting growth in research and need for a formal biostatistics component to address the complex multidimensional and longitudinal relationships. Since renewal, Dr. Beckett has led the Statistics and Data Management Core, working closely with Dr. Mungas, who has continued to oversee the data management aspect of the Core. We have recruited a second biostatistician, Dr. Danielle Harvey, who has developed both strong collaborative and independent research in AD. Drs. Beckett, Harvey and Mungas have worked together to integrate statistics and data management with the other cores of the UCD ADC.
Specific Aims for this Core are to: 1) continue systematic data collection, entry, and management, 2) provide statistical consultations for investigators working with the ADC, 3) foster the development of new statistical methodology to address research questions of the UCD ADC, and 4) assist in the mentoring and training of students and new researchers in the area of Alzheimer's disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010129-20
Application #
8078875
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
20
Fiscal Year
2010
Total Cost
$173,071
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Meyer, Oanh L; Liu, Xiaoyan; Nguyen, Thuc-Nhi et al. (2018) Psychological Distress of Ethnically Diverse Adult Caregivers in the California Health Interview Survey. J Immigr Minor Health 20:784-791
Fletcher, Evan; Filshtein, Teresa Jenica; Harvey, Danielle et al. (2018) Staging of amyloid ?, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses. Alzheimers Dement (Amst) 10:382-393
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Mungas, Dan; Gavett, Brandon; Fletcher, Evan et al. (2018) Education amplifies brain atrophy effect on cognitive decline: implications for cognitive reserve. Neurobiol Aging 68:142-150
Lian, Chunfeng; Liu, Mingxia; Zhang, Jun et al. (2018) Automatic Segmentation of 3D Perivascular Spaces in 7T MR Images Using Multi-Channel Fully Convolutional Network. Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson M 2018:
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Rangaraju, Srikant; Dammer, Eric B; Raza, Syed Ali et al. (2018) Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease. Mol Neurodegener 13:24
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Chen, Yi-Je; Nguyen, Hai M; Maezawa, Izumi et al. (2018) Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann Clin Transl Neurol 5:147-161

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