The UCD ADC added a formal biostatistics component to its successful data management program at the time of renewal in 2001, reflecting growth in research and need for a formal biostatistics component to address the complex multidimensional and longitudinal relationships. Since renewal, Dr. Beckett has led the Statistics and Data Management Core, working closely with Dr. Mungas, who has continued to oversee the data management aspect of the Core. We have recruited a second biostatistician, Dr. Danielle Harvey, who has developed both strong collaborative and independent research in AD. Drs. Beckett, Harvey and Mungas have worked together to integrate statistics and data management with the other cores of the UCD ADC.
Specific Aims for this Core are to: 1) continue systematic data collection, entry, and management, 2) provide statistical consultations for investigators working with the ADC, 3) foster the development of new statistical methodology to address research questions of the UCD ADC, and 4) assist in the mentoring and training of students and new researchers in the area of Alzheimer's disease.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1)
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University of California Davis
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Wong, Jonathan M; Gray, John A (2018) Long-Term Depression Is Independent of GluN2 Subunit Composition. J Neurosci 38:4462-4470
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Seiler, Stephan; Fletcher, Evan; Hassan-Ali, Kinsy et al. (2018) Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition. Neurobiol Aging 72:14-22
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Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104
Gavett, Brandon E; Fletcher, Evan; Harvey, Danielle et al. (2018) Ethnoracial differences in brain structure change and cognitive change. Neuropsychology 32:529-540
Burke, Shanna L; Cadet, Tamara; Maddux, Marlaina (2018) Chronic Health Illnesses as Predictors of Mild Cognitive Impairment Among African American Older Adults. J Natl Med Assoc 110:314-325
Sarnowski, Chloé; Satizabal, Claudia L; DeCarli, Charles et al. (2018) Whole genome sequence analyses of brain imaging measures in the Framingham Study. Neurology 90:e188-e196
Gilsanz, Paola; Mayeda, Elizabeth Rose; Glymour, M Maria et al. (2018) Birth in High Infant Mortality States and Dementia Risk in a Cohort of Elderly African American and White Health Care Members. Alzheimer Dis Assoc Disord :
Mungas, Dan; Early, Dawnté R; Glymour, M Maria et al. (2018) Education, bilingualism, and cognitive trajectories: Sacramento Area Latino Aging Study (SALSA). Neuropsychology 32:77-88

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