The University of California, Davis Alzheimer's Disease Center (UCD ADC) has evolved to focus upon the scientific theme of exploring the heterogeneity of AD in a racially and ethnically diverse population. This theme developed in response to the unique strengths of the personnel involved with the ADC, success in minority recruitment and a number of newly funded research programs supported by the ADC. In addition, the ADC will continue to support and develop research related to AD and the related dementias both locally and nationally through its many collaborations. The ADC is composed of 6 cores: Administrative, Clinical, Education and Information Transfer (EITC), Pathology, Biostatistics and Data Management, and Neuroimaging. The Administrative Core provides overall guidance for scientific, policy, and procedural aspects of the ADC in addition to ensuring collaboration and communication throughout the ADC program. The Clinical Core will evaluate patients and controls to provide a large cohort of AD patients with research diagnostic evaluations who are available for cross sectional studies as well as studies that will collect additional data and a racially and ethnically diverse longitudinally followed cohort of subjects with normal cognition, mild cognitive impairment and dementia. This cohort will include individuals with coexisting cerebrovascular disease who are followed to autopsy. Minority recruitment will continue through successful outreach. The Neuropathology Core will perform brain retrieval for subjects in the longitudinal cohort who have enrolled in the autopsy program, will characterize the extent and severity of Alzheimer and cerebrovascular pathology, and maintain a bank of fixed and frozen tissue and DNA. The EITC will provide education to both the community and professionals, as well as assist in recruitment of minority subjects to the longitudinal cohort. The Neuroimaging Core will acquire MRI and PET data on members of the longitudinal cohort and provide quantitative and semi-quantitative data on white matter hyperintensities, hippocampal atrophy, and cerebral atrophy. The Data Management and Statistics Core will provide both statistical support and consulting to ADC research, and will maintain the already operational database that links all components of the ADC to one another to facilitate cross disciplinary research and reporting requirements.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG010129-20S2
Application #
8053611
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (M1))
Program Officer
Silverberg, Nina B
Project Start
1997-07-15
Project End
2011-08-31
Budget Start
2010-08-01
Budget End
2011-08-31
Support Year
20
Fiscal Year
2010
Total Cost
$63,000
Indirect Cost
Name
University of California Davis
Department
Neurology
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Marino, Simeone; Xu, Jiachen; Zhao, Yi et al. (2018) Controlled feature selection and compressive big data analytics: Applications to biomedical and health studies. PLoS One 13:e0202674
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Insel, Philip S; Hansson, Oskar; Mackin, R Scott et al. (2018) Amyloid pathology in the progression to mild cognitive impairment. Neurobiol Aging 64:76-84
Meyer, Oanh L; Leggett, Amanda; Liu, Siwei et al. (2018) Prevalence and correlates of subjective memory complaints in Vietnamese adults. Int Psychogeriatr 30:1039-1048
Riedel, Brandalyn C; Daianu, Madelaine; Ver Steeg, Greg et al. (2018) Uncovering Biologically Coherent Peripheral Signatures of Health and Risk for Alzheimer's Disease in the Aging Brain. Front Aging Neurosci 10:390
Swinford, Cecily G; Risacher, Shannon L; Charil, Arnaud et al. (2018) Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition. Alzheimers Dement (Amst) 10:322-331
Bangen, Katherine J; Preis, Sarah R; Delano-Wood, Lisa et al. (2018) Baseline White Matter Hyperintensities and Hippocampal Volume are Associated With Conversion From Normal Cognition to Mild Cognitive Impairment in the Framingham Offspring Study. Alzheimer Dis Assoc Disord 32:50-56
Fletcher, Evan; Filshtein, Teresa Jenica; Harvey, Danielle et al. (2018) Staging of amyloid ?, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses. Alzheimers Dement (Amst) 10:382-393
Meyer, Oanh L; Liu, Xiaoyan; Nguyen, Thuc-Nhi et al. (2018) Psychological Distress of Ethnically Diverse Adult Caregivers in the California Health Interview Survey. J Immigr Minor Health 20:784-791

Showing the most recent 10 out of 1156 publications