Research during the last 5 years has uniquely positioned the University of California, Davis Alzheimer's Disease Center (UCD ADC) to advance scientific understanding along the theme of how various risk and protective conditions differentially affect cognitive trajectories across the spectrum of cognitive ability. Our approach is enabled and enhanced by the unique experiences, skills, and methods facilitated by the UCD ADC Cores and their interactions. These skills include development or refinement of new methods along with development of new conceptual models and the coordinated application of these resources towards common goals. These efforts are further extended by extensive collaborations with other scientists, NACC and the NIA. Importantly, these efforts are part of an integrated and growing research program at UC Davis that is uniquely suited to studying the complex determinants of cognitive decline associated with diseases of aging and dementia. Consisting of 6 Cores, the UCD ADC approach to supporting ongoing research is based on the belief that AD exists within the wider context of other factors that affect cognitive function. Unraveling the multiple deleterious and protective factors that ultimately determine the variance in course of cognitive function with advancing age, however, remains an enormous challenge. To meet this challenge, the Clinical Core developed methods to enhance subject diversity amongst the participants within the longitudinal cohort of the UCD ADC leading to recruitment of a highly diverse study population that varies across multiple dimensions. We also developed novel assessment tools which were used to acquire further research funding in support of the general themes and available resources of the UCD ADC. This approach, built around a diverse and longitudinally followed cohort of subjects, serves as the core resource for an integrated research effort that is guided by five essential principals: innovation, integration, leverage, growth and training. In this application we present successful progress over the previous grant cycle and propose nbvel and unique approaches to guide the succeeding five years in order to continue to productively contribute to advancing our understanding of conditions the influence cognitive aging and incident dementia.

Public Health Relevance

A variety of protective and risk conditions exist and combine to result in widely varying trajectories of cognitive aging. Understanding the sources for this heterogeneity is a central issue to research that has both scientific significance and clinical relevance, including relevance for potential treatment. Unraveling the multiple deleterious and protective factors that ultimately determine the variance in course of cognitive function with advancing aae is the goal of the UCD ADC.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG010129-24S1
Application #
8866304
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Silverberg, Nina B
Project Start
1997-07-15
Project End
2016-06-30
Budget Start
2014-09-01
Budget End
2015-06-30
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Davis
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Davis
State
CA
Country
United States
Zip Code
95618
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Jena, Prasant Kumar; Sheng, Lili; Di Lucente, Jacopo et al. (2018) Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. FASEB J 32:2866-2877
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Maezawa, Izumi; Nguyen, Hai M; Di Lucente, Jacopo et al. (2018) Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain 141:596-612
Meyer, Oanh L; Liu, Xiaoyan Lucia; Tancredi, Daniel et al. (2018) Acculturation level and caregiver outcomes from a randomized intervention trial to enhance caregivers' health: evidence from REACH II. Aging Ment Health 22:730-737
Fletcher, Evan; Gavett, Brandon; Harvey, Danielle et al. (2018) Brain volume change and cognitive trajectories in aging. Neuropsychology 32:436-449
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Dadar, Mahsa; Maranzano, Josefina; Ducharme, Simon et al. (2018) Validation of T1w-based segmentations of white matter hyperintensity volumes in large-scale datasets of aging. Hum Brain Mapp 39:1093-1107
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161

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