The Alzheimer's Disease Center Core (ADCC) will build upon and enhance the resources available at Emory to create a foundation upon which research on Alzheimer's disease (AD) will grow. To facilitate this growth, clinical and research activities on the Emory Campus, nearby Wesley Woods and VA Medical Centers, as well as Grady Memorial Hospital in downtown Atlanta have been coordinated. The Administrative Core is organized to foster a collegial and stimulating environment with maximum interaction of ADCC and other investigators. In a setting of quality patient care and family support, the Clinical Core will provide a well characterized population of AD patients and cognitively normal individuals thus creating a comprehensive database from which clinical, epidemiological, and basic scientific studies will emanate. Proactive minority outreach will be emphasized by clinical and educational initiatives in cooperation with community and other groups. Capitalizing upon the strengths and interests of Emory faculty in the genetics and biochemistry of oxidative phosphorylation (OXPHOS) and oxygen radical damage to DNA and its repair, we have added a Molecular Biology Core to the ADCC. This core will assist in the metabolic and genetic characterization of AD patients and control subjects of varying age and provide new opportunities for AD research. The Neuropathology Core will supply brain and other appropriate tissues from well characterized dementia and control cases to the Molecular Core and to other investigators through maintenance of an active brain bank for acquisition, storage, handling, and distribution of tissue. Neuropathological information will be pooled with clinical and biochemical and genetic data to provide a sound base for clinical and basic scientific investigations. Participation of epidemiologists and biostatisticians from the Emory School of Public Health will support ADCC study design and analysis. The Education and Information Transfer Core will provide innovative programs for professionals caregivers and other lay groups. In combination with strong institutional and community support, the Emory ADCC will be catalyst for new research in AD.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Neuroscience, Behavior and Sociology of Aging Review Committee (NBSA)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
Schools of Medicine
United States
Zip Code
Goldstein, Felicia C; Levey, Allan I; Steenland, N Kyle (2013) High blood pressure and cognitive decline in mild cognitive impairment. J Am Geriatr Soc 61:67-73
Procaccio, Vincent; Salazar, Gloria; Ono, Shoichiro et al. (2006) A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. Am J Hum Genet 78:947-60
Goldstein, F C; Ashley, A V; Freedman, L J et al. (2005) Hypertension and cognitive performance in African Americans with Alzheimer disease. Neurology 64:899-901
Choi, Joungil; Levey, Allan I; Weintraub, Susan T et al. (2004) Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J Biol Chem 279:13256-64
Weiner, David M; Goodman, Matilda W; Colpitts, Tonya M et al. (2004) Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias. Am J Pharmacogenomics 4:119-28
Cairns, Nigel J; Zhukareva, Victoria; Uryu, Kunihiro et al. (2004) alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. Am J Pathol 164:2153-61
Scherzer, Clemens R; Offe, Katrin; Gearing, Marla et al. (2004) Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol 61:1200-5
Cairns, Nigel J; Uryu, Kunihiro; Bigio, Eileen H et al. (2004) alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Acta Neuropathol (Berl) 108:213-23
Cairns, N J; Grossman, M; Arnold, S E et al. (2004) Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease. Neurology 63:1376-84
Gearing, Marla; Juncos, Jorge L; Procaccio, Vincent et al. (2002) Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia. Ann Neurol 52:465-76

Showing the most recent 10 out of 85 publications