The Indiana Alzheimer Disease Center (IADC) is established on the facilities of Indiana University School of Medicine. It will comprise five cores: an Administrative Core, Clinical Core, Data Management and Statistics Core, Neuropathology Core, and an Education and Information Transfer Core. The Director and two Associate Co-Directors of the Center are Dr. Bernardino Ghetti (Distinguished Professor of Pathology &Laboratory Medicine, Psychiatry, Medical &Molecular Genetics, and Neurology), Dr. Hugh C. Hendrie (Professor of Psychiatry) and Dr. Martin R. Farlow (Professor of Neurology). The strength of the IADC lays in its multidisciplinary faculty that has contributed significantly in the fields of Psychiatry, Neurology, Neuropathology, Medical and Molecular Genetics. The IADC interacts with other multidisciplinary clinical and research programs at Indiana University, the graduate programs in Medical Neurobiology and Genetics, the Indiana University Center for Aging Research and the Stark Neurosciences Research Institute. The Core Leaders have an established record in medical care, research related to Alzheimer disease (AD) and related dementias with particular emphasis on hereditary dementias. The IADC has developed and will continue to foster community relationships and educational programs in cooperation with the Alzheimer's Association, Central Indiana Chapter and other community agencies. The major strengths of the IADC are the clinicopathologic and molecular studies on atypical and hereditary dementias, the trials for new drug therapy for AD, and other hereditary dementias, and the educational activities. The IADC will continue to support research endeavors in dementia by facilitating research interactions, sharing knowledge of faculty and their laboratory facilities, and providing an environment to faculty, graduates and students of Indiana University School of Medicine that generates interest in dementia research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010133-20
Application #
7893001
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (M1))
Program Officer
Silverberg, Nina B
Project Start
1997-07-15
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
20
Fiscal Year
2010
Total Cost
$1,695,412
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Pathology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Risacher, Shannon L; Farlow, Martin R; Bateman, Daniel R et al. (2018) Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET. Acta Neuropathol Commun 6:114
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Ridge, Perry G; Wadsworth, Mark E; Miller, Justin B et al. (2018) Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping. Alzheimers Dement 14:514-519
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Di Fede, Giuseppe; Catania, Marcella; Maderna, Emanuela et al. (2018) Molecular subtypes of Alzheimer's disease. Sci Rep 8:3269
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Konar, Arpita; Kumar, Ashish; Maloney, Bryan et al. (2018) A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling. Sci Rep 8:9928

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