The Indiana Alzheimer Disease Center (IADC) is established on the facilities of Indiana University School of Medicine. It will comprise five cores: an Administrative Core, Clinical Core, Data Management and Statistics Core, Neuropathology Core, and an Education and Information Transfer Core. The Director and two Associate Co-Directors of the Center are Dr. Bernardino Ghetti (Distinguished Professor of Pathology &Laboratory Medicine, Psychiatry, Medical &Molecular Genetics, and Neurology), Dr. Hugh C. Hendrie (Professor of Psychiatry) and Dr. Martin R. Farlow (Professor of Neurology). The strength of the IADC lays in its multidisciplinary faculty that has contributed significantly in the fields of Psychiatry, Neurology, Neuropathology, Medical and Molecular Genetics. The IADC interacts with other multidisciplinary clinical and research programs at Indiana University, the graduate programs in Medical Neurobiology and Genetics, the Indiana University Center for Aging Research and the Stark Neurosciences Research Institute. The Core Leaders have an established record in medical care, research related to Alzheimer disease (AD) and related dementias with particular emphasis on hereditary dementias. The IADC has developed and will continue to foster community relationships and educational programs in cooperation with the Alzheimer's Association, Central Indiana Chapter and other community agencies. The major strengths of the IADC are the clinicopathologic and molecular studies on atypical and hereditary dementias, the trials for new drug therapy for AD, and other hereditary dementias, and the educational activities. The IADC will continue to support research endeavors in dementia by facilitating research interactions, sharing knowledge of faculty and their laboratory facilities, and providing an environment to faculty, graduates and students of Indiana University School of Medicine that generates interest in dementia research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010133-20
Application #
7893001
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (M1))
Program Officer
Silverberg, Nina B
Project Start
1997-07-15
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
20
Fiscal Year
2010
Total Cost
$1,695,412
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Pathology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Khan, Sikandar; Biju, Ashok; Wang, Sophia et al. (2018) Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial. Trials 19:94
Brelstaff, Jack; Tolkovsky, Aviva M; Ghetti, Bernardino et al. (2018) Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell Rep 24:1939-1948.e4
Cong, Shan; Risacher, Shannon L; West, John D et al. (2018) Volumetric comparison of hippocampal subfields extracted from 4-minute accelerated vs. 8-minute high-resolution T2-weighted 3T MRI scans. Brain Imaging Behav 12:1583-1595
Miller, Jason E; Shivakumar, Manu K; Risacher, Shannon L et al. (2018) Codon bias among synonymous rare variants is associated with Alzheimer's disease imaging biomarker. Pac Symp Biocomput 23:365-376
Swinford, Cecily G; Risacher, Shannon L; Charil, Arnaud et al. (2018) Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition. Alzheimers Dement (Amst) 10:322-331
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Davis, Jeremy J (2018) Performance validity in older adults: Observed versus predicted false positive rates in relation to number of tests administered. J Clin Exp Neuropsychol 40:1013-1021
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Lin, Ming; Gong, Pinghua; Yang, Tao et al. (2018) Big Data Analytical Approaches to the NACC Dataset: Aiding Preclinical Trial Enrichment. Alzheimer Dis Assoc Disord 32:18-27

Showing the most recent 10 out of 604 publications