The purpose of the Administrative Core is (1) to provide overall direction and provide fiscal management for the Indiana Alzheimer Disease Center (IADC), (2) to coordinate and integrate the activities of the IADC components, (3) to encourage research into Alzheimer disease (AD) and related disorders by the faculty at Indiana University School of Medicine and (4) to encourage, evaluate, support and supervise the conduct of the pilot project. The Core Leader is Dr. Bernardino Ghetti. He will be assisted by an Associate Co-Director Dr. Martin R. Farlow. One of the IADC missions is that of nurturing new research in AD and related dementias and of encouraging new investigators to develop research interests in areas of AD. Two pilot projects will be available annually through the IADC. Junior investigators from Indiana University are encouraged to apply. A call for research proposals will be made annually to all chairpersons and directors of centers, institutes and divisions within Indiana University and Purdue University as well as other selected institutions that do not have an Alzheimer disease center.

Public Health Relevance

It is estimated that as many as 5 million Americans have AD. The Indiana Alzheimer Disease Center provides an environment and resources directed towards fostering and coordinating research and educational activities on AD and other dementing illnesses.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010133-23
Application #
8502588
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
23
Fiscal Year
2013
Total Cost
$259,972
Indirect Cost
$91,160
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Falcon, Benjamin; Zhang, Wenjuan; Murzin, Alexey G et al. (2018) Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature 561:137-140
Wang, Sophia; Hammes, Jessica; Khan, Sikandar et al. (2018) Improving Recovery and Outcomes Every Day after the ICU (IMPROVE): study protocol for a randomized controlled trial. Trials 19:196
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Khan, Sikandar; Biju, Ashok; Wang, Sophia et al. (2018) Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial. Trials 19:94
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Cong, Shan; Risacher, Shannon L; West, John D et al. (2018) Volumetric comparison of hippocampal subfields extracted from 4-minute accelerated vs. 8-minute high-resolution T2-weighted 3T MRI scans. Brain Imaging Behav 12:1583-1595
Brelstaff, Jack; Tolkovsky, Aviva M; Ghetti, Bernardino et al. (2018) Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell Rep 24:1939-1948.e4
Miller, Jason E; Shivakumar, Manu K; Risacher, Shannon L et al. (2018) Codon bias among synonymous rare variants is associated with Alzheimer's disease imaging biomarker. Pac Symp Biocomput 23:365-376
Swinford, Cecily G; Risacher, Shannon L; Charil, Arnaud et al. (2018) Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition. Alzheimers Dement (Amst) 10:322-331

Showing the most recent 10 out of 604 publications