Abstract

? Clinical Core (CC) The Clinical Core is critical to the function of the Indiana Alzheimer Disease Center. Its role is to recruit, clinically characterize and longitudinally follow patients with MCI, AD, non-AD and mixed dementia and healthy controls. A major emphasis is to identify and clinically characterize patients in the presymptomatic and prodromal stages including those from familial AD and non-AD dementia kindreds. These patients will be further characterized by the Neuroimaging, Genetics, Biomarker and Bioinformatics and Neuropathology Cores. Patients from the Clinical Core will be offered as appropriate participation in ADNI, DIAN, LOAD, investigational drug trials and other local and multicenter research studies. We will continue to support NACC, NCRAD and other local, regional, national and international projects. In addition, we will collaborate with the Research Education Component and Recruitment and Education Cores to provide education and training opportunities to researchers and trainees at all levels and to educate and support affected participants, family members, and the community at large.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010133-30
Application #
9977794
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
30
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Li, Wei; Risacher, Shannon L; Gao, Sujuan et al. (2018) Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid ?1-42 in Alzheimer's Disease Neuroimaging Initiative participants. Alzheimers Dement (Amst) 10:94-98
Wang, Xiaoqian; Chen, Hong; Yan, Jingwen et al. (2018) Quantitative trait loci identification for brain endophenotypes via new additive model with random networks. Bioinformatics 34:i866-i874
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Risacher, Shannon L; Farlow, Martin R; Bateman, Daniel R et al. (2018) Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET. Acta Neuropathol Commun 6:114
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Ridge, Perry G; Wadsworth, Mark E; Miller, Justin B et al. (2018) Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping. Alzheimers Dement 14:514-519

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