The goal of the Neuropathology Core of Alzheimer's Disease Center Core is to provide brain tissue to researchers from Alzheimer's disease and control patients who have had thorough clinical evaluations, have been followed regularly premortem, and have had an extensive neuropathological evaluation postmortem. The Rush Alzheimer's Disease Center already has numerous patients coming to autopsy with Alzheimer's disease and plans to implement two methods to obtain comparable numbers of control patients. The proposed protocol for harvesting the brains of these patients will provide well- fixed and quickly frozen brain tissue with short autolysis times to investigators. Each Alzheimer's disease and control patient will be comprehensively evaluated by a neuropathologist using the standard criteria for the diagnosis of Alzheimer's disease and other non-Alzheimer's disease dementias. These data will be reviewed in a monthly meeting with the Clinical Core to promote correlative studies and identify atypical cases. These data and specimens will be stored and indexed to allow quick retrieval and distribution to investigators. Through the procedures outlined above, the Neuropathology Core will meet its ultimate goal of facilitating research investigators and will maximize its potential as a valuable resource of the ADCC.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Rush University Medical Center
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Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Haljas, Kadri; Amare, Azmeraw T; Alizadeh, Behrooz Z et al. (2018) Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits. Psychosom Med 80:242-251
Yu, Lei; Petyuk, Vladislav A; Gaiteri, Chris et al. (2018) Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. Ann Neurol 84:78-88
Jansen, Willemijn J; Wilson, Robert S; Visser, Pieter Jelle et al. (2018) Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging 61:138-145
Benedet, Andréa L; Yu, Lei; Labbe, Aurélie et al. (2018) CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem. Neurol Genet 4:e216
Tan, Chin Hong; Fan, Chun Chieh; Mormino, Elizabeth C et al. (2018) Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol 135:85-93
Arvanitakis, Zoe; Leurgans, Sue E; Fleischman, Debra A et al. (2018) Memory complaints, dementia, and neuropathology in older blacks and whites. Ann Neurol 83:718-729
Blue, Elizabeth E; Bis, Joshua C; Dorschner, Michael O et al. (2018) Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord 45:1-17

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