The goal of the Clinical Core is to provide clinical resources to facilitate high quality clinical, neuropsychological, epidemiological and neuropathological research in Alzheimer's disease. There are three major operational components in the Clinical Core: 1) A uniform structured baseline clinical evaluation classifies subjects as to the presence or absence of Alzheimer's disease, collects initial psychometric, behavioral and physical function data for comparison with subsequent evaluations to permit measurement of change in these variables, and provides investigators with a uniform and comprehensive description of these variables to ensure a uniform common data set across a wide range of ongoing and future externally funded studies. 2) The branched annual follow-up evaluation was designed to achieve two general purposes. First, to provide a source of well characterized cases and controls with clinical status documented proximate to death to facilitate neuropathological studies. Second, to provide a pool of subjects for studies. 3) To efficiently distribute subjects into clinical, neuropsychological, epidemiological and neuropathological studies, consecutive subjects evaluated by the Core, determined to be eligible for one or more of a variety of externally funded studies will be recruited in a manner which minimizes the burden of studies on patients, their families and staff. To meet these goals, the Clinical Core will build on its successes during the first project period. From March 2, 1992 though August 15, 1995, 1837 persons underwent highly structured uniform clinical evaluations by the Clinical Core. Of these persons, 896 (48.8%) were distributed into in one or more of 20 externally funded studies, including studies requiring large numbers of persons with varying diagnoses across a wide range dementia severity to studies with highly restrictive entry requirements. Minority participation was also high; minorities comprised 18.1% of Clinical Core subjects and 19.2% of study participants.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010161-08
Application #
6267534
Study Section
Project Start
1998-07-01
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
McAninch, Elizabeth A; Rajan, Kumar B; Evans, Denis A et al. (2018) A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans. J Clin Endocrinol Metab 103:1818-1826
Power, Melinda C; Mormino, Elizabeth; Soldan, Anja et al. (2018) Combined neuropathological pathways account for age-related risk of dementia. Ann Neurol 84:10-22
Samieri, C├ęcilia; Morris, Martha-Clare; Bennett, David A et al. (2018) Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons. Am J Epidemiol 187:933-940
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Bennett, David A (2018) Lack of Benefit With Idalopirdine for Alzheimer Disease: Another Therapeutic Failure in a Complex Disease Process. JAMA 319:123-125
Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Lee, Catherine; Betensky, Rebecca A; Alzheimer's Disease Neuroimaging Initiative (2018) Time-to-event data with time-varying biomarkers measured only at study entry, with applications to Alzheimer's disease. Stat Med 37:914-932
Lamar, Melissa; Yu, Lei; Rubin, Leah H et al. (2018) APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. Alzheimers Dement :

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