Abstract

The Alzheimer's Disease Center (ADC) will be a separately identified entity composed of those individuals and resources at the University of Kansas Medical Center and its affiliates that are devoted to care, education, and research in Alzheimer's Disease (AD) and related subjects. The ADC's purpose will be to encourage, abet, support, assist, and accomplish research which will contribute to understanding of the prevalence, cause, prevention and treatment of AD. The ADC will be organized around the four center cores which will be provided by this grant and will include activities and structures currently devoted to AD and related subjects. The ADC Associates will include those individuals responsible for each of the center cores as well as investigators involved in research on AD and related problems as well as others contributing material and intellectual resources. The Associates will be members of the faculties of the University of Kansas Medical Center, the Lawrence Campus of the University and affiliated institutions and agencies, particularly those providing clinical and community service. The organization and governance of the ADC will be described in the section that describes the Administrative Core. The Key Personnel and Associates are listed in the following pages.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
1P30AG010182-01
Application #
3101016
Study Section
Neuroscience, Behavior and Sociology of Aging Review Committee (NBSA)
Project Start
1991-09-30
Project End
1996-06-30
Budget Start
1991-09-30
Budget End
1992-06-30
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Kansas
Department
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

SantaCruz, Karen S; Yazlovitskaya, Eugenia; Collins, Julie et al. (2004) Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease. Neurobiol Aging 25:63-9
Woods, Steven Paul; Troster, Alexander I (2003) Prodromal frontal/executive dysfunction predicts incident dementia in Parkinson's disease. J Int Neuropsychol Soc 9:17-24
Kemper, S; Marquis, J; Thompson, M (2001) Longitudinal change in language production: effects of aging and dementia on grammatical complexity and propositional content. Psychol Aging 16:600-14
Sheffield, L G; Marquis, J G; Berman, N E (2000) Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer's disease. Neurosci Lett 285:165-8
Geroldi, C; Laakso, M P; DeCarli, C et al. (2000) Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study. J Neurol Neurosurg Psychiatry 68:93-6
Wang, Y; Santa-Cruz, K; DeCarli, C et al. (2000) NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Aalzheimer's disease. Neurobiol Aging 21:525-31
Arnold, P M; Ma, J Y; Citron, B A et al. (1999) Insulin-like growth factor binding proteins in cerebrospinal fluid during human development and aging. Biochem Biophys Res Commun 264:652-6
Geroldi, C; Pihlajamaki, M; Laakso, M P et al. (1999) APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD. Neurology 53:1825-32
Sheffield, L G; Berman, N E (1998) Microglial expression of MHC class II increases in normal aging of nonhuman primates. Neurobiol Aging 19:47-55
Ellis, R J; Jan, K; Kawas, C et al. (1998) Diagnostic validity of the dementia questionnaire for Alzheimer disease. Arch Neurol 55:360-5

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