The neuropathology core will coordinate the acquisition, processing, storage and distribution of autopsy material. Detailed histopathologic descriptions will form the foundation on which our allied research facilities can delineate the subtle differences in our clinically well characterized patient population. A clinical cohort consisting of 200 Alzheimer's patients, 100 patients with both Alzheimer's and Parkinsonian features, 50 non-demented Parkinsonian patients and 50 age-matched controls, all periodically evaluated with neuropsychological assessments, will ultimately form the bulk of our neuropathology specimens. The brains of patients suffering other rare dementing diseases of great scientific interest such as Pick's, Huntington's chorea, progressive supranuclear palsy, aged Down's Syndrome etc. will be evaluated when obtained. With an estimated mortality rate of 5-10%/year for patients with these diseases, we expect to collect approximately 20 brains/yr. and have 100 specimens at the end of five years. The protocol is compulsive and yet flexible so that it can be easily modified and/or expanded to incorporate additional patient groups, developing research techniques and evolving scientific questions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG010182-05
Application #
6295563
Study Section
Project Start
1995-07-15
Project End
1999-04-30
Budget Start
Budget End
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
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