Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG013314-04S1
Application #
6216417
Study Section
Project Start
1999-09-01
Project End
2001-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Azhar, Gohar; Zhang, Xiaomin; Wang, Sophie et al. (2007) Maintaining serum response factor activity in the older heart equal to that of the young adult is associated with better cardiac response to isoproterenol stress. Basic Res Cardiol 102:233-44
Zhang, Xiaomin; Azhar, Gohar; Furr, Maxwell C et al. (2003) Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor. Am J Physiol Regul Integr Comp Physiol 285:R552-60
Nekhaeva, Ekaterina; Bodyak, Natalya D; Kraytsberg, Yevgenya et al. (2002) Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A 99:5521-6
Pugh, K G; Wei, J Y (2001) Clinical implications of physiological changes in the aging heart. Drugs Aging 18:263-76
Zhang, X; Azhar, G; Nagano, K et al. (2001) Differential vulnerability to oxidative stress in rat cardiac myocytes versus fibroblasts. J Am Coll Cardiol 38:2055-62
Fang, L; Li, G; Liu, G et al. (2001) p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades. EMBO J 20:1931-9
Bodyak, N D; Nekhaeva, E; Wei, J Y et al. (2001) Quantification and sequencing of somatic deleted mtDNA in single cells: evidence for partially duplicated mtDNA in aged human tissues. Hum Mol Genet 10:17-24
Memili, E; Hong, Y K; Kim, D H et al. (2001) Murine Xist RNA isoforms are different at their 3' ends: a role for differential polyadenylation. Gene 266:131-7
Zhang, X; Chai, J; Azhar, G et al. (2001) Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor. J Biol Chem 276:40033-40
Hong, Y K; Ontiveros, S D; Strauss, W M (2000) A revision of the human XIST gene organization and structural comparison with mouse Xist. Mamm Genome 11:220-4

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