Abstract

This core will provide a centralized facility for assaying cytogenetic abnormalities and gene mutations, focused on the analysis of rodent model systems as a function of age. The Core is comprised of four major components: (i) It will provide measurements of cytogenetic integrity and DNA mutations and will additionally offer advice concerning aspects of genome instability such as monitoring of DNA damage, analysis of microsatellite instability, and methylation patterns. (ii) The Core contains a training component aimed at providing the users with advice in selecting the best assays for the model system being investigated and, most importantly, in interpreting results. (iii) As a general educational component, workshops will be organized to inform the San Antonio aging research community about progress in genomic instability and aging and to inform the group about new and emerging technologies. (iv) Effort will be devoted to continue the development and optimization of currently used assays for analysis of cytogenetic and mutational endpoints in aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG013319-08S1
Application #
6615156
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2002-08-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Salmon, Adam B; Dorigatti, Jonathan; Huber, Hillary F et al. (2018) Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions. Geroscience 40:269-278
Gelfond, Jonathan; Goros, Martin; Hernandez, Brian et al. (2018) A System for an Accountable Data Analysis Process in R. R J 10:6-21
Sills, Aubrey M; Artavia, Joselyn M; DeRosa, Brian D et al. (2018) Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Am J Primatol :e22927
Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N et al. (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246-1256
Unnikrishnan, Archana; Hadad, Niran; Masser, Dustin R et al. (2018) Revisiting the genomic hypomethylation hypothesis of aging. Ann N Y Acad Sci 1418:69-79
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394
Lee, Hak Joo; Feliers, Denis; Barnes, Jeffrey L et al. (2018) Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience 40:163-176
Kang, Donghoon; Kirienko, Daniel R; Webster, Phillip et al. (2018) Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. Virulence 9:804-817
Hook, Michael; Roy, Suheeta; Williams, Evan G et al. (2018) Genetic cartography of longevity in humans and mice: Current landscape and horizons. Biochim Biophys Acta Mol Basis Dis 1864:2718-2732

Showing the most recent 10 out of 231 publications