The definitive diagnosis of Alzheimer's disease (AD) can only be reached through the microscopic investigation of brain tissue. The Neuropathology Core will establish an infrastructure for timely autopsies and for the microscopic investigation of brain specimens from the control and dementia subjects enrolled in the Clinical Core of the ADCC. The Core will also accept control and dementia specimens from a cohort of neuropsychologically investigated subjects who are enrolled in a brain endowment program coordinated by the NIH-funded University of Miami Brain Endowment Bank. The tissue will be processed in a manner that allows systematic and uniform diagnostic procedures with traditional stains as well as more quantitative determinations of tangle density, amyloid burden, synaptic density and the integrity of selected transmitter pathways with the help of sensitive immunohistochemical procedures. Tissue will also be stored in unfixed-frozen, fixed-unembedded, fixed- paraffin-embedded, and fixed-and-frozen-sectioned form. These various combinations have been chosen in order to address the wide spectrum of requirements described by the 22 investigators at Northwestern University who plan to use the resources of the Neuropathology Core for their research. The investigation of all specimens will include a broad anatomical survey that will allow relevant clinico-pathological correlations with the neuropsychological domains that will be assessed by the Clinical Core. Some of the specimens will be processed in whole-hemisphere sections in order to address the requirement of some research projects for extensive anatomical and cytoarchitectonic detail.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013854-03
Application #
6267683
Study Section
Project Start
1998-07-15
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Ohm, D T; Kim, G; Gefen, T et al. (2018) Prominent microglial activation in cortical white matter is selectively associated with cortical atrophy in primary progressive aphasia. Neuropathol Appl Neurobiol :
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Tirrell, Timothy F; Rademaker, Alfred W; Lieber, Richard L (2018) Analysis of hierarchical biomechanical data structures using mixed-effects models. J Biomech 69:34-39
Gefen, Tamar; Ahmadian, Saman S; Mao, Qinwen et al. (2018) Combined Pathologies in FTLD-TDP Types A and C. J Neuropathol Exp Neurol 77:405-412
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679

Showing the most recent 10 out of 443 publications