Abstract

The specific aims of the Clinical Core, under the direction of Dr. Jared Tinklenberg, are: 1) to recruit Alzheimer's Disease (AD) and dementia with Lewy bodies (DLB) patients, individuals with Mild Cognitive Impairment (MCI), and normals, and perform baseline and longitudinal evaluations that will further characterize them for Center-enabled Associated Research. Selected assessments relevant to R0-1-type applications and cooperative treatment studies would include behavioral, neurological, neuropsychological and background measures, 2) enrolling patients and controls into the Center's autopsy program, in collaboration with the Neuropathology Core, and maintain regular, frequent contacts with enrollees to maximize autopsy rates through a carefully developed set of pre-arrangements, and 3) collecting cerebrospinal fluid (CSF) and blood samples from patients and controls for banking by the Neuropathology Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG017824-03S1
Application #
6669192
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2002-09-30
Project End
2003-04-30
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Kawai, Makoto; Beaudreau, Sherry A; Gould, Christine E et al. (2016) Delta Activity at Sleep Onset and Cognitive Performance in Community-Dwelling Older Adults. Sleep 39:907-14
Garrett, A; Gupta, S; Reiss, A L et al. (2015) Impact of 5-HTTLPR on hippocampal subregional activation in older adults. Transl Psychiatry 5:e639
Tinklenberg, Jared R; Kraemer, Helena C; Yaffe, Kristine et al. (2015) Donepezil treatment in ethnically diverse patients with Alzheimer disease. Am J Geriatr Psychiatry 23:384-90
Adamson, Maheen M; Taylor, Joy L; Heraldez, Daniel et al. (2014) Higher landing accuracy in expert pilots is associated with lower activity in the caudate nucleus. PLoS One 9:e112607
Waring, Jill D; Etkin, Amit; Hallmayer, Joachim F et al. (2014) Connectivity underlying emotion conflict regulation in older adults with 5-HTTLPR short allele: a preliminary investigation. Am J Geriatr Psychiatry 22:946-50
Schröder, Carmen M; Primeau, Michelle M; Hallmayer, Joachim F et al. (2014) Serotonin transporter polymorphism is associated with increased apnea-hypopnea index in older adults. Int J Geriatr Psychiatry 29:227-35
OýýHara, Ruth; Marcus, Peter; Thompson, Wesley K et al. (2012) 5-HTTLPR short allele, resilience, and successful aging in older adults. Am J Geriatr Psychiatry 20:452-6
Davies, Helen D; Sridhar, Sneha B; Newkirk, Lori A et al. (2012) Gender differences in sexual behaviors of AD patients and their relationship to spousal caregiver well-being. Aging Ment Health 16:89-101
Thompson, Wesley K; Hallmayer, Joachim; O'Hara, Ruth et al. (2011) Design considerations for characterizing psychiatric trajectories across the lifespan: application to effects of APOE-?4 on cerebral cortical thickness in Alzheimer's disease. Am J Psychiatry 168:894-903
Adamson, Maheen M; Hutchinson, J Benjamin; Shelton, Amy L et al. (2011) Reduced hippocampal activity during encoding in cognitively normal adults carrying the APOE ?4 allele. Neuropsychologia 49:2448-55

Showing the most recent 10 out of 63 publications