The Data Management and Statistics Core (DMSC) provides comprehensive data management, high quality statistical, experimental design support and neuroimaging processing/analysis assistance for the Arizona ADC. The core assures and maintains data accuracy and accessibility for the center's investigators, facilitates the sharing of data with collaborators, and guarantees full compliance with the National Alzheimer's Coordinating Center (NACC). The DMSC also supports new research, acts as catalyst to prompt collaborations inside and outside Arizona, and actively engages in the development, testing, and implementation of novel analytic methods and software. In response to the constructive and insightful prior review of the DMSC from 2011, we reorganized DMSC and are pleased to have Dr. Kewei Chen join Dr. Graciela Gonzalez to co-chair the DMSC. Dr. Chen will lead the statistics efforts, while Dr. Gonzalez will continue to lead all data management efforts. With expertise in statistics, database, neuroimaging, and novel statistical methods development, the DMSC is poised to advance basic, clinical, and intervention research in the early detection, tracking, and prevention of AD. We propose four aims to facilitate high impact bench-to-bedside, translational research: (1) To provide comprehensive data management for acquisition, organization, use, and sharing of data from participants enrolled and followed, (2) To provide statistical, experimental design, and neuroimaging analysis support for new and ongoing projects, (3) To develop, test, and implement new statistical, image analytic, and data management methods and applications to advance the goals of the Arizona ADC, and (4) To actively facilitate research collaborations both inside and outside Arizona to advance the goals and objectives of our center. We will be replacing our old MSAccess database with a new centralized, integrated database that will link imaging and genomic data to the UDS data. It will also allow direct entry from each ADC site via a secure web application, and include a web-based querying system for researchers across our geographically distributed center. Statistical assistance will be provided by the newly formed Statistical Analysis Workgroup consisting of Drs. Chen, Wilson, Alexander, Langbaum and Dueck. Finally, we establish metrics for the data program's development and routine provision of ADCC performance to help the Executive Committee monitor performance and progress and modify its activities accordingly.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG019610-20
Application #
9755290
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
20
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Arizona State University-Tempe Campus
Department
Type
DUNS #
943360412
City
Tempe
State
AZ
Country
United States
Zip Code
85287
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Pal, Gian; Ouyang, Bichun; Verhagen, Leo et al. (2018) Probing the striatal dopamine system for a putative neuroprotective effect of deep brain stimulation in Parkinson's disease. Mov Disord 33:652-654
Li, Zeran; Del-Aguila, Jorge L; Dube, Umber et al. (2018) Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure. Genome Med 10:43
Sabbagh, Marwan N; Shi, Jiong; Lee, Moonhee et al. (2018) Salivary beta amyloid protein levels are detectable and differentiate patients with Alzheimer's disease dementia from normal controls: preliminary findings. BMC Neurol 18:155
Tse, Kai-Hei; Cheng, Aifang; Ma, Fulin et al. (2018) DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia. Alzheimers Dement 14:664-679
Walker, Douglas G; Tang, Tiffany M; Lue, Lih-Fen (2018) Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains. Exp Neurol 309:91-106
Schaffert, Jeff; LoBue, Christian; White, Charles L et al. (2018) Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease. Neuropsychology 32:410-416
Wu, Jianfeng; Zhang, Jie; Shi, Jie et al. (2018) HIPPOCAMPUS MORPHOMETRY STUDY ON PATHOLOGY-CONFIRMED ALZHEIMER'S DISEASE PATIENTS WITH SURFACE MULTIVARIATE MORPHOMETRY STATISTICS. Proc IEEE Int Symp Biomed Imaging 2018:1555-1559
Cabrera, Erwin; Mathews, Paul; Mezhericher, Emiliya et al. (2018) A? truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition. Biochim Biophys Acta Mol Basis Dis 1864:208-225

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