The Biolmaging Resource Core (BIRC) provides leadership, scientific expertise and instrumental supportin quantitative imaging techniques, including MRI, CT, DXA and PET, critical to the WFU OAlC's researchtheme: Integrating pathways affecting physical function for new approaches to disability prevention. TheBIRC is well integrated with all WFU OAIC cores and leads the development and implementation of imagingtechniques and protocols to quantify and characterize body composition, particularly skeletal muscle andtotal, regional and organ-specific adipose tissue and to obtain non-invasive measures of vascular andneuromuscular function. The Core also supports a large image repository that it developed during thepresent cycle in order to facilitate cross-study comparisons and exploratory analyses of established imagingoutcomes as well as rapid development and validation of new imaging phenotypes. Methods developedduring the current cycle have been demonstrated to be robust and of high precision in both human researchand in translational models using rodents and nonhuman primates. During the present cycle, the BIRC hasstrongly contributed to the strong success of the OAIC by supporting 3,431 image acquisitions (DXA, CT, MRIand PET) in 10 externally-supported studies, 8 pilot studies and 3 research development projects.
The specific aims of the Biolmaging Resource Core are to: 1) determine the associations of age anddisease-related changes in skeletal muscle and adipose tissue depots with biological, genetic, co-morbid,psychosocial and behavioral factors, and other outcomes relevant to physical function; 2) measure the effectsof interventions (dietary/nutritional, exercise, pharmacologic, and combinations) on adipose and skeletalmuscle tissue depots; 3) use in vivo bio-imaging to enable bi-directional translation of key findings betweenhumans and animal models (including nonhuman primates) in support of mechanistic research; 4) developand validate novel non-invasive imaging metrics which allow improved characterization of skeletal muscle,adipose tissue and vascular function in older adults to be integrated with a standardized battery of physicalfunction and laboratory/molecular assessments.The BIRC leadership team are highly experienced and successful investigators who have strategicallycomplementary skill sets and strong records of collaborative scientific and administrative achievements. Inthe initial year, the BIRC will support 7 externally-funded projects, 2 pilot projects and 1 developmentalproject. The BIRC will also provide training and mentoring to RCDC-supported faculty to develop expertise inimaging techniques and to advance their development as independent translational research scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG021332-06
Application #
7422515
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
2008-08-01
Project End
2013-05-31
Budget Start
2008-08-01
Budget End
2009-05-31
Support Year
6
Fiscal Year
2008
Total Cost
$125,912
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Liu, Zuyun; Hsu, Fang-Chi; Trombetti, Andrea et al. (2018) Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial. BMC Med 16:185
Stacey, R Brandon; Vera, Trinity; Morgan, Timothy M et al. (2018) Asymptomatic myocardial ischemia forecasts adverse events in cardiovascular magnetic resonance dobutamine stress testing of high-risk middle-aged and elderly individuals. J Cardiovasc Magn Reson 20:75
Bakhru, Rita N; Davidson, James F; Bookstaver, Rebecca E et al. (2018) Physical function impairment in survivors of critical illness in an ICU Recovery Clinic. J Crit Care 45:163-169
Custodero, C; Mankowski, R T; Lee, S A et al. (2018) Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis. Ageing Res Rev 46:42-59
Buford, Thomas W; Manini, Todd M; Kairalla, John A et al. (2018) Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc 7:e010009
Manini, Todd M; Buford, Thomas W; Kairalla, John A et al. (2018) Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed. Geroscience 40:497-511
Berry, Michael J; Sheilds, Katherine L; Adair, Norman E (2018) Comparison of Effects of Endurance and Strength Training Programs in Patients with COPD. COPD 15:192-199
Rosso, Andrea L; Metti, Andrea L; Glynn, Nancy W et al. (2018) Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc 66:1172-1179
Shea, M Kyla; Loeser, Richard F; McAlindon, Timothy E et al. (2018) Association of Vitamin K Status Combined With Vitamin D Status and Lower-Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts. Arthritis Care Res (Hoboken) 70:1150-1159
Nagpal, Ravinder; Wang, Shaohua; Solberg Woods, Leah C et al. (2018) Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces. Front Microbiol 9:2897

Showing the most recent 10 out of 603 publications