The goal of the OAIC Pilot/Exploratory Studies Core (PESC) is to develop the key information needed toselect and design future definitive, original studies with a high potential to advance our understanding ofunderlying mechanisms of and preventive interventions for physical disability in older Americans. This goal isachieved by soliciting, fostering, selecting, and then promoting promising innovative pilot and exploratorystudies that address the OAIC research theme: Integrating pathways affecting physical function for newapproaches to disability prevention. The PESC manages the project review and selection process,including facilitating the independent review of the advisory panel. The Core then promotes the funded pilot/exploratory studies by ensuring the availability of optimal infrastructure, guidance, environment, funding,expertise, and instrumentation. PESC leaders actively monitor study progress, assist in analysis andinterpretation of results, and provide guidance in translating pilot data into full, high-quality, original researchstudy proposals that will successfully compete for independent extramural funding. The PESC has been akey component in the outstanding success of the Wake Forest OAIC by promoting new, externally fundedstudies (n=56; total $23.8 million), generating relevant, high-impact publications (n=334; 5821 SCI citations),and training junior faculty for research (n=15).The PESC is well integrated with all OAIC cores, and is particularly tightly integrated with the ResearchCareer Development Core (RCDC). By providing funding and expertise to design and execute welldesigned,relevant pilot and exploratory studies, the PESC helps ensure junior investigators develop theneeded preliminary data for successful career development and independent research applications. ThePESC also seeks and guides more senior investigators, including from other disciplines, to broaden and refocustheir efforts to develop novel, integrated approaches to problems relevant to the OAIC theme. A newinnovation of the PESC will be the development and dissemination of a program to train and assistinvestigators in developing appropriate pilot project proposals.The PESC co-leaders are two well-established investigators, one in basic and one in clinical agingresearch, who are highly successful independently, have strategically complementary skill sets, and haveexemplary records of achievement in collaborating scientifically and administratively to develop and mentornew investigators in translational research. In the first year, the OAIC Pilot/Exploratory Studies Coreproposes to fund four pilot studies, comprised of both clinical and basic research studies, human and animalstudies, and mechanistic and intervention studies. This broad, integrated, collaborative approach fostersmultiple levels of translation between basic and clinical research in order to advance our understanding ofpathways affecting physical function and development of new approaches to disability prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG021332-06
Application #
7422517
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
2008-08-01
Project End
2013-05-31
Budget Start
2008-08-01
Budget End
2009-05-31
Support Year
6
Fiscal Year
2008
Total Cost
$128,995
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Kim, Sunghye; Miller, Michael E; Lin, Marina et al. (2018) Self- vs proxy-reported mobility using the mobility assessment tool-short form in elderly preoperative patients. Eur Rev Aging Phys Act 15:5
Anton, Stephen D; Moehl, Keelin; Donahoo, William T et al. (2018) Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring) 26:254-268
Datta, Rupak; Trentalange, Mark; Van Ness, Peter H et al. (2018) Serious adverse events of older adults in nursing home and community intervention trials. Contemp Clin Trials Commun 9:77-80
Justice, Jamie N; Ferrucci, Luigi; Newman, Anne B et al. (2018) A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. Geroscience 40:419-436
Mokhtari, Fatemeh; Rejeski, W Jack; Zhu, Yingying et al. (2018) Dynamic fMRI networks predict success in a behavioral weight loss program among older adults. Neuroimage 173:421-433
Schoell, Samantha L; Beavers, Kristen M; Beavers, Daniel P et al. (2018) Prediction of lumbar vertebral body compressive strength of overweight and obese older adults using morphed subject-specific finite-element models to evaluate the effects of weight loss. Aging Clin Exp Res :
Miller, Michael E; Magaziner, Jay; Marsh, Anthony P et al. (2018) Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations. J Am Geriatr Soc 66:954-961
Trombetti, Andrea; Hars, Mélany; Hsu, Fang-Chi et al. (2018) Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med 168:309-316
Pastva, Amy M; Duncan, Pamela W; Reeves, Gordon R et al. (2018) Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial. Contemp Clin Trials 64:118-127
Maggiore, Ronald J; Callahan, Kathryn E; Tooze, Janet A et al. (2018) Geriatrics fellowship training and the role of geriatricians in older adult cancer care: A survey of geriatrics fellowship directors. Gerontol Geriatr Educ 39:170-182

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