This proposal seeks renewal of an Older Americans Independence Center at the Johns Hopkins Medical Institutions. The focus of this Center is to promote independence for frail older adults through the development of interventions to prevent or ameliorate frailty and the many serious, adverse outcomes that frail older adults are at risk for. To accomplish this, a multidisciplinary group of senior and junior investigators, in multiple departments and Programs at this institution, propose to continue and enhance, through this OAIC, 1. the Leadership Council that will stimulate, lead and sustain a University-wide interdisciplinary research program investigating frailty, its etiology and opportunities for treatment; 2. the infrastructure and methodologic development essential to creating the next generations of research on frailty in older adults; 3. support for the career development of outstanding junior faculty committed to research careers that will lead to treatments for frailty and its prevention; and 4. to cultivate and support pilot studies that will provide the basis for investigator-initiated and funded research towards interventions on frailty. The OAIC would provide the support critical to complement and harness the substantial strengths already at this institution into a unified and potent effort directed at developing interventions for frailty. It is designed to ensure multidisciplinary translation between basic, mechanistic and clinical/population-based research, and of each into development of treatments for frailty. This organized infrastructure and scientific leadership will serve as a source of advice and collaborations to investigators at our own institution and at other institutions in the area of research on frailty in aging. The OAIC will be administratively led by, and housed in, the Johns Hopkins Center on Aging and Health, with strong leadership and participation by all of the institutional programs committed to aging research; it will also seek to expand to incorporate leaders and investigators not previously involved in research on frailty but who have made a commitment to this work through the planning process for this proposal. This OAIC has strong institutional commitment, based on the priority at the Medical Institutions for the unification and strengthening of aging research and spotlighting its importance for the entire institution. Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults. ? ? PROGRAM AS A WHOLE ? ? ?

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Program Officer
Nayfield, Susan G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Public Health & Prev Medicine
Schools of Public Health
United States
Zip Code
Fitzpatrick, Jessica; Sozio, Stephen M; Jaar, Bernard G et al. (2018) Frailty, body composition and the risk of mortality in incident hemodialysis patients: the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease study. Nephrol Dial Transplant :
Skarupski, Kimberly A; Gross, Alden; Schrack, Jennifer A et al. (2018) The Health of America's Aging Prison Population. Epidemiol Rev 40:157-165
McAdams-DeMarco, Mara A; Ying, Hao; Thomas, Alvin G et al. (2018) Frailty, Inflammatory Markers, and Waitlist Mortality Among Patients With End-stage Renal Disease in a Prospective Cohort Study. Transplantation 102:1740-1746
Walston, Jeremy; Buta, Brian; Xue, Qian-Li (2018) Frailty Screening and Interventions: Considerations for Clinical Practice. Clin Geriatr Med 34:25-38
Wanigatunga, Amal A; Varadhan, Ravi; Simonsick, Eleanor M et al. (2018) Longitudinal Relationship between Interleukin-6 and Perceived Fatigability among well-functioning Adults in mid-to-late Life. J Gerontol A Biol Sci Med Sci :
Walker, Keenan A; Walston, Jeremy; Gottesman, Rebecca F et al. (2018) Midlife Systemic Inflammation is Associated with Frailty in Later Life: The ARIC Study. J Gerontol A Biol Sci Med Sci :
Warsame, Fatima; Ying, Hao; Haugen, Christine E et al. (2018) Intradialytic Activities and Health-Related Quality of Life Among Hemodialysis Patients. Am J Nephrol 48:181-189
Hall, Rasheeda K; McAdams-DeMarco, Mara A (2018) Breaking the cycle of functional decline in older dialysis patients. Semin Dial 31:462-467
Simonsick, Eleanor M; Aronson, Benjamin; Schrack, Jennifer A et al. (2018) Lumbopelvic Pain and Threats to Walking Ability in Well-Functioning Older Adults: Findings from the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc 66:714-720
Martinez-Amezcua, Pablo; Matsushita, Kunihiro; Simonsick, Eleanor M et al. (2018) Fatigability and functional performance among older adults with low-normal ankle-brachial index: Cross-sectional findings from the Baltimore Longitudinal Study of Aging. Atherosclerosis 272:200-206

Showing the most recent 10 out of 251 publications