The overall goal of the Yale Research Career Development Core (RCDC) is to identify and train a cadre ofjunior investigators who will be future leaders in aging research, with the skills necessary to design/conductbiological, translational, and clinical studies of multifactorial geriatric health conditions.
The specific aims are: (1) to promote the career development and acquisition of research skills of selected junior facultythrough the provision of salary, infrastructure/technical, and other career development support; (2) to provideand facilitate priority access by junior faculty to the resource cores' expertise and services for the design,conduct, and analysis of studies addressing multifactorial geriatric health conditions; (3) to promote thedevelopment of skills for translational research (basic clinical basic; clinical > practice) that addressesour focus on multifactorial geriatric health conditions; (4) to identify and foster opportunities forinterdisciplinary research; (5) to sponsor a yearly junior faculty retreat that provides intensive training andsupport in research career development; (6) to provide and facilitate access to educational activities in agingresearch locally and nationally; and (7) to enhance access to other career development resources, such asprotocol development, information on funding sources, grant resource library, suitable mentors andcollaborators, appropriate study populations, and geriatric instrument catalog. As reflected in these aims,there will be a greater emphasis during the next funding cycle on translational and interdisciplinary research.Dr. Thomas Gill, an NIH-funded clinical investigator with international stature for his work on functionaldecline and disability and with proven leadership and mentorship abilities, will lead the RCDC. For the firstyear, 4 candidates of outstanding promise, representing different disciplines with diverse backgrounds andinterests, have been selected: Sarwat Chaudhry, MD (General Medicine), Manisha Juthani-Mehta, MD(Infectious Disease), Arthur Simen, MD, PhD (Molecular Psychiatry and Human Genetics), and Ji Li, PhD(Cardiology). Successful renewal of the Older Americans Independence Center (OAIC) will allow us to buildon many of the successful procedures that we have established over the past 15 years and to continue toaddress the scarcity of clinical, translational and basic science investigators with optimal skills and training torigorously study the etiology, prognosis and management of multifactorial geriatric health conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG021342-06
Application #
7424114
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
2008-08-15
Project End
2013-05-31
Budget Start
2008-08-15
Budget End
2009-05-31
Support Year
6
Fiscal Year
2008
Total Cost
$492,991
Indirect Cost
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Gill, Thomas M; Han, Ling; Leo-Summers, Linda et al. (2018) Distressing Symptoms, Disability, and Hospice Services at the End of Life: Prospective Cohort Study. J Am Geriatr Soc 66:41-47
Liu, Zu-Yun; Wei, Yin-Zhi; Wei, Li-Qing et al. (2018) Frailty transitions and types of death in Chinese older adults: a population-based cohort study. Clin Interv Aging 13:947-956
Monin, Joan K; Xu, Annie; Mitchell, Hannah-Rose et al. (2018) Recalling support provision decreases distress and anger in response to partner suffering. Aging Ment Health 22:587-594
Gill, Thomas M; Gahbauer, Evelyne A; Leo-Summers, Linda et al. (2018) Days Spent at Home in the Last Six Months of Life Among Community-Living Older Persons. Am J Med :
Wang, Christina; Stephens-Shields, Alisa J; DeRogatis, Leonard R et al. (2018) Validity and Clinically Meaningful Changes in the Psychosexual Daily Questionnaire and Derogatis Interview for Sexual Function Assessment: Results From the Testosterone Trials. J Sex Med 15:997-1009
Marini, Sandro; Devan, William J; Radmanesh, Farid et al. (2018) 17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage. Stroke 49:1618-1625
Buford, Thomas W; Manini, Todd M; Kairalla, John A et al. (2018) Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc 7:e010009
McCoy, Rozalina G; Herrin, Jeph; Lipska, Kasia J et al. (2018) Recurrent hospitalizations for severe hypoglycemia and hyperglycemia among U.S. adults with diabetes. J Diabetes Complications 32:693-701
Shook, Brett A; Wasko, Renee R; Rivera-Gonzalez, Guillermo C et al. (2018) Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science 362:
Miller, Michael E; Magaziner, Jay; Marsh, Anthony P et al. (2018) Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations. J Am Geriatr Soc 66:954-961

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