The Biomechanics Research Core, henceforth called the ?Biomechanics Core,? (BC) will enable its personnel to devote time to assist and train investigators in the conduct of new and expanded research on how metabolic disease and inflammation interact with age-related disease to determine key health outcomes related to mobility and functional status, the biomechanics of aging, and to the training of geriatric physicians and other clinicians in the biomechanics relevant to impaired mobility, falls and fall-related injuries, urinary incontinence and prolapse in the elderly. They also will enable substantial use by Core-supported investigators of the equipment and facilities that exist in the Biomechanics Research Laboratory of the Department of Mechanical Engineering, as well as facilities in the Mobility Research Laboratory at the Geriatrics Center. The present request seeks to accomplish several unmet goals, integrate new ideas, and to broaden the Core activities into new areas. These include the energetics of walking in frail elderly, losses of balance and falls in the elderly, urinary incontinence, prolapse and fecal incontinence in older women. Economic efficiencies are gained in terms of equipment and service through this core structure rather than duplicating separate biomechanics components to each. Since its inception, the Core has served as a consulting service to faculty performing multidisciplinary research into geriatric mobility problems. It has thus provided advice which might otherwise be harder to obtain if it did not exist. This consistency in turn impacts in a positive sense the quality of the research conducted at the Institution as witnessed by the record of peer-reviewed publications, successful young investigators, and the K12, K23, R21, R01, and SCOR (P50) grants awarded.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG024824-12
Application #
9095192
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
12
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Turcu, Adina F; Nanba, Aya T; Auchus, Richard J (2018) The Rise, Fall, and Resurrection of 11-Oxygenated Androgens in Human Physiology and Disease. Horm Res Paediatr 89:284-291
Schoeni, Robert F; Freedman, Vicki A; Langa, Kenneth M (2018) Introduction to a Supplement on Population Level Trends in Dementia: Causes, Disparities, and Projections. J Gerontol B Psychol Sci Soc Sci 73:S1-S9
Mau, Theresa; Yung, Raymond (2018) Adipose tissue inflammation in aging. Exp Gerontol 105:27-31
Garratt, Michael; Lagerborg, Kim A; Tsai, Yi-Miau et al. (2018) Male lifespan extension with 17-? estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice. Aging Cell :e12786
Molnar, L J; Eby, D W; Vivoda, J M et al. (2018) The effects of demographics, functioning, and perceptions on the relationship between self-reported and objective measures of driving exposure and patterns among older adults. Transp Res Part F Traffic Psychol Behav 54:367-377
Rao, Krishna; Higgins, Peter D R; Young, Vincent B (2018) An Observational Cohort Study of Clostridium difficile Ribotype 027 and Recurrent Infection. mSphere 3:
Garratt, Michael; Stout, Michael B (2018) Hormone actions controlling sex-specific life-extension. Aging (Albany NY) 10:293-294
Maust, Donovan T; Kim, H Myra; Chiang, Claire et al. (2018) Association of the Centers for Medicare & Medicaid Services' National Partnership to Improve Dementia Care With the Use of Antipsychotics and Other Psychotropics in Long-term Care in the United States From 2009 to 2014. JAMA Intern Med 178:640-647
Eby, David W; Molnar, Lisa J; Zakrajsek, Jennifer S et al. (2018) Prevalence, attitudes, and knowledge of in-vehicle technologies and vehicle adaptations among older drivers. Accid Anal Prev 113:54-62
Cho, Chun-Seok; Park, Hwan-Woo; Ho, Allison et al. (2018) Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. Hepatology 68:1331-1346

Showing the most recent 10 out of 424 publications