Abstract

The goal of the Pilot/Exploratory Studies Core is to promote innovative multidisciplinary research related to mobility, balance and aging. The P/ESC manages the process of promotion, application, review, award and monitoring for Pilot/Exploratory Studies and Developmental projects. Priorities for awards include relevance to the OAIC theme, potential for independent funding, new multidisciplinary collaboration and translational potential. Additional priorities for Development Projects are potential to advance research methods in the area of mobility, balance and aging, degree of innovation and potential for incorporation into OAIC future studies. In order to make the most efficient use of resources, projects that serve as add-ons to existing funded studies are encouraged. Proposed first year pilot studies include PES-i: Role of NF-kB in stem cells in aging, PES-2: Pre-operative treatment with electrical stimulation enhances aged muscle regenerative capacity and return to functional mobility post-operatively, PES-3 Investigation into the Mechanisms of Symptom Relief with Forward Flexion in Older Patients with Spinal Stenosis and PES-4:Variability, Stability and Smoothness of Walking.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG024827-07
Application #
8124939
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
7
Fiscal Year
2010
Total Cost
$85,480
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Xiong, Jianhua; Kawagishi, Hiroyuki; Yan, Ye et al. (2018) A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Mol Cell 69:689-698.e7
Gurkar, Aditi U; Robinson, Andria R; Cui, Yuxiang et al. (2018) Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol 18:191-199
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Pérez, Laura M; Roqué, Marta; Glynn, Nancy W et al. (2018) Validation of the Spanish version of the Pittsburgh Fatigability Scale for older adults. Aging Clin Exp Res :
Justice, Jamie N; Ferrucci, Luigi; Newman, Anne B et al. (2018) A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. Geroscience 40:419-436
Agimi, Yll; Albert, Steven M; Youk, Ada O et al. (2018) Dementia and motor vehicle crash hospitalizations: Role of physician reporting laws. Neurology 90:e808-e813
Miller, Michael E; Magaziner, Jay; Marsh, Anthony P et al. (2018) Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations. J Am Geriatr Soc 66:954-961
Gellad, Walid F; Thorpe, Joshua M; Zhao, Xinhua et al. (2018) Impact of Dual Use of Department of Veterans Affairs and Medicare Part D Drug Benefits on Potentially Unsafe Opioid Use. Am J Public Health 108:248-255
Trombetti, Andrea; Hars, Mélany; Hsu, Fang-Chi et al. (2018) Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med 168:309-316
Jacob, Mini E; Marron, Megan M; Boudreau, Robert M et al. (2018) Age, Race, and Gender Factors in Incident Disability. J Gerontol A Biol Sci Med Sci 73:194-197

Showing the most recent 10 out of 1292 publications