The focus of the UTMB OAK is age-related sarcopenia and its contribution to loss of independence in older persons. The UTMB OAIC will support investigators studying the pathogenesis, consequences, prevention and treatment of sarcopenia. These investigations will be at multiple levels: at the level of the cell (proteomics, genomics, enzyme activities), at the level of muscle tissue (physiologic studies of muscle metabolism), at the level of the organism (clinical trials of interventions to improve strength and physical functioning) and at the level of human populations. Most of the studies supported by the OAIC involve several of these levels, requiring interdisciplinary teams of investigators to effectively address the question under study. The UTMB OAIC Focus is limited to a single tissue, muscle, a single condition, aging, and (with few exceptions) a single species, humans. This tight focus facilitates interdisciplinary communication and drives translational research.
The specific aims of the UTMB OAK are as follows: 1.) Provide core support to funded interdisciplinary translational research on age-related sarcopenia by UTMB investigators and investigators at other OAICs. 2.) Stimulate the growth of additional interdisciplinary translational research projects in age-related sarcopenia by: a.) funding pilot project research to generate preliminary data in promising new areas of investigation. b.) funding developmental projects to develop innovative technologies for the study of sarcopenia. 3.) Train future leaders in research in the causes, pathophysiology, prevention and treatment of age-related sarcopenia. 4.) Recruit established investigators with expertise relevant to sarcopenia into interdisciplinary translational research on age-related sarcopenia. 5.) Foster collaborations between UTMB investigators and investigators at other institutions on studies of age related sarcopenia.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (M3))
Program Officer
Nayfield, Susan G
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University of Texas Medical Br Galveston
Internal Medicine/Medicine
Schools of Medicine
United States
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Downer, Brian; González-González, Cesar; Goldman, Noreen et al. (2018) The effect of adult children living in the United States on the likelihood of cognitive impairment for older parents living in Mexico. Ethn Health 23:57-71
Baillargeon, Jacques; Kuo, Yong-Fang; Westra, Jordan R et al. (2018) Testosterone Prescribing in the United States, 2002-2016. JAMA 320:200-202
Housten, Ashley J; Pappadis, Monique R; Krishnan, Shilpa et al. (2018) Resistance to discontinuing breast cancer screening in older women: A qualitative study. Psychooncology 27:1635-1641
Kuo, Yong-Fang; Raji, Mukaila A; Liaw, Victor et al. (2018) Opioid Prescriptions in Older Medicare Beneficiaries After the 2014 Federal Rescheduling of Hydrocodone Products. J Am Geriatr Soc 66:945-953
Hoover, Diana S; Pappadis, Monique R; Housten, Ashley J et al. (2018) Preferences for Communicating about Breast Cancer Screening Among Racially/Ethnically Diverse Older Women. Health Commun :1-5
Pappadis, Monique R; Volk, Robert J; Krishnan, Shilpa et al. (2018) Perceptions of overdetection of breast cancer among women 70 years of age and older in the USA: a mixed-methods analysis. BMJ Open 8:e022138
Middleton, Addie; Li, Shuang; Kuo, Yong-Fang et al. (2018) New Institutionalization in Long-Term Care After Hospital Discharge to Skilled Nursing Facility. J Am Geriatr Soc 66:56-63
Deer, Rachel R; Volpi, Elena (2018) Protein Requirements in Critically Ill Older Adults. Nutrients 10:
Chao, Tony; Porter, Craig; Herndon, David N et al. (2018) Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. Med Sci Sports Exerc 50:427-435
Graber, Ted G; Rawls, Brandy L; Tian, Bing et al. (2018) Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100

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