Skeletal muscle atrophy is an important pathological process in the sarcopenia of advancing age, spinal cord injury, and models of enervation and muscle disuse. The purpose of this Proteomics and Genomics Core Facility (PGCF) is to provide state-of-the art experimental resources and the development of new procedures that facilitate understanding the molecular genetic and biochemical mechanisms of sarcopenia development and the biological interactions of recovery. These approaches provide basic information on understanding the molecular and genetic mechanisms of development and recovery of skeletal muscle atrophies that include age-associated sarcopenia (UTMB) and muscle frailty (JHU), spinal cord injury and hemiparetic stroke (UM), and cardiovascular disease (WF), and the complex molecular biological processes leading to rehabilitation and recovery. All of these areas of research are of major interest of many of the Pepper OAICs and serve to unify the investigations at these centers. There are three Specific Aims of the PGCF:
Aim, 1 focuses upon the development and improvement of proteomics and genomics high throughput technologies for use by Pepper OAIC investigators;
Aim 2, focuses upon the continuation and extension of the on-going collaborations with Pepper OAIC investigators;
Aim 3, focuses upon the training of young investigators in areas of molecular genomics and proteomics. An important function of the PGCF is to provide rapid, efficient and state-of-the art investigation and identification of the biological processes affected by the muscle atrophies and those essential to recovery. Such processes as global gene expression, organellar (mitochondrial) gene expression and biogenesis, changes in protein pool levels, and protein modifications associated with skeletal muscle pathology can be identified and thereby provide the basic information needed to understand the molecular mechanisms of muscle atrophy and recovery. These studies ultimately provide information for the design of pharmaceutical interventions.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Medical Br Galveston
United States
Zip Code
Housten, Ashley J; Pappadis, Monique R; Krishnan, Shilpa et al. (2018) Resistance to discontinuing breast cancer screening in older women: A qualitative study. Psychooncology 27:1635-1641
Kuo, Yong-Fang; Raji, Mukaila A; Liaw, Victor et al. (2018) Opioid Prescriptions in Older Medicare Beneficiaries After the 2014 Federal Rescheduling of Hydrocodone Products. J Am Geriatr Soc 66:945-953
Hoover, Diana S; Pappadis, Monique R; Housten, Ashley J et al. (2018) Preferences for Communicating about Breast Cancer Screening Among Racially/Ethnically Diverse Older Women. Health Commun :1-5
Pappadis, Monique R; Volk, Robert J; Krishnan, Shilpa et al. (2018) Perceptions of overdetection of breast cancer among women 70 years of age and older in the USA: a mixed-methods analysis. BMJ Open 8:e022138
Middleton, Addie; Li, Shuang; Kuo, Yong-Fang et al. (2018) New Institutionalization in Long-Term Care After Hospital Discharge to Skilled Nursing Facility. J Am Geriatr Soc 66:56-63
Deer, Rachel R; Volpi, Elena (2018) Protein Requirements in Critically Ill Older Adults. Nutrients 10:
Chao, Tony; Porter, Craig; Herndon, David N et al. (2018) Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. Med Sci Sports Exerc 50:427-435
Graber, Ted G; Rawls, Brandy L; Tian, Bing et al. (2018) Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100
Lewis, Zakkoyya H; Markides, Kyriakos S; Ottenbacher, Kenneth J et al. (2018) The Impact of 10-Year Physical Activity Changes on 7-Year Mortality in Older Mexican Americans. J Phys Act Health 15:30-39
Li, Shuang; Middleton, Addie; Ottenbacher, Kenneth J et al. (2018) Trajectories Over the First Year of Long-Term Care Nursing Home Residence. J Am Med Dir Assoc 19:333-341

Showing the most recent 10 out of 408 publications