The specific aims of the UTMB Claude Pepper Older Americans Independence Center (OAIC) are to: 1) provide core support to funded translational research by UTMB investigators on muscle function and functional recovery in older adults; 2) Stimulate the growth of additional interdisciplinary translational research projects to improve muscle function and functional recovery in older adults by: a) funding pilot project research to generate preliminary data in promising new areas of investigation and b) funding developmental projects to develop innovative technologies; 3) Train future leaders in research in the mechanisms, prevention and treatment of muscle dysfunction and disability in older adults; 4) Recruit established investigators with expertise relevant to muscle function and functional recovery in older adults into interdisciplinary translational research related to the OAIC focus and 5) Foster collaborations between UTMB investigators and investigators at other OAIC and other institutions on studies of muscle function and functional recovery in older adults. The theme for the next cycle of our OAIC is: Translating Biological Mechanisms of Muscle Growth and Loss to Improve Function and Recovery in Older Adults. Our focus is on translating basic discoveries on the mechanisms of muscle loss and re-growth with aging to clinical practice to promote functional recovery and prevent disability in older adults. Observational studies will provide crucial information for selecting appropriate in-hospital, post-discharge, and long-term outcomes for inclusion in clinical trials of geriatric patient populations. Our general hypothesis is that aging induces mild but significant changes in muscle biology and function that progressively lead to muscle loss and predispose to potentially catastrophic declines in muscle mass and function during bouts of acute illness. We also hypothesize that anabolic interventions involving exercise/rehabilitation, amino acid/protein supplementation and hormonal or other pharmacological treatment can prevent the age- and disease-induced muscle loss and reduce the risk of

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG024832-08
Application #
8572186
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (A1))
Project Start
2005-06-15
Project End
2015-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
8
Fiscal Year
2012
Total Cost
$232,324
Indirect Cost
$80,479
Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Markofski, Melissa M; Jennings, Kristofer; Timmerman, Kyle L et al. (2018) Effect of Aerobic Exercise Training and Essential Amino Acid Supplementation for 24 Weeks on Physical Function, Body Composition and Muscle Metabolism in Healthy, Independent Older Adults: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci :
Downer, Brian; Garcia, Marc A; Saenz, Joseph et al. (2018) The Role of Education in the Relationship Between Age of Migration to the United States and Risk of Cognitive Impairment Among Older Mexican Americans. Res Aging 40:411-431
Saenz, Joseph L; Wong, Rebeca; Ailshire, Jennifer A (2018) Indoor air pollution and cognitive function among older Mexican adults. J Epidemiol Community Health 72:21-26
Garcia, Marc A; Saenz, Joseph; Downer, Brian et al. (2018) The role of education in the association between race/ethnicity/nativity, cognitive impairment, and dementia among older adults in the United States. Demogr Res 38:155-168
Saenz, Joseph L; Downer, Brian; Garcia, Marc A et al. (2018) Cognition and Context: Rural-Urban Differences in Cognitive Aging Among Older Mexican Adults. J Aging Health 30:965-986
Smith, Theresa M; Pappadis, Monique R; Krishnan, Shilpa et al. (2018) Stroke Survivor and Caregiver Perspectives on Post-Stroke Visual Concerns and Long-Term Consequences. Behav Neurol 2018:1463429
Middleton, Addie; Downer, Brian; Haas, Allen et al. (2018) Functional Status Is Associated With 30-Day Potentially Preventable Readmissions Following Skilled Nursing Facility Discharge Among Medicare Beneficiaries. J Am Med Dir Assoc 19:348-354.e4
Downer, Brian; Al Snih, Soham; Howrey, Bret T et al. (2018) Combined effects of cognitive impairment and pre-frailty on future frailty and death in older Mexican Americans. Aging Ment Health :1-8
Goodwin, James S; Salameh, Habeeb; Zhou, Jie et al. (2018) Association of Hospitalist Years of Experience With Mortality in the Hospitalized Medicare Population. JAMA Intern Med 178:196-203
Salinas, Jennifer J; Gonzalez, Jennifer M Reingle; Al Snih, Soham (2018) Type 2 diabetes, depressive symptoms and disability over a 15-year follow-up period in older Mexican Americans living in the southwestern United States. J Diabetes Complications 32:75-82

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