The specific aims of the UTMB Claude Pepper Older Americans Independence Center (OAIC) are to: 1) provide core support to funded translational research by UTMB investigators on muscle function and functional recovery in older adults;2) Stimulate the growth of additional interdisciplinary translational research projects to improve muscle function and functional recovery in older adults by: a) funding pilot project research to generate preliminary data in promising new areas of investigation and b) funding developmental projects to develop innovative technologies;3) Train future leaders in research in the mechanisms, prevention and treatment of muscle dysfunction and disability in older adults;4) Recruit established investigators with expertise relevant to muscle function and functional recovery in older adults into interdisciplinary translational research related to the OAIC focus and 5) Foster collaborations between UTMB investigators and investigators at other OAIC and other institutions on studies of muscle function and functional recovery in older adults. The theme for the next cycle of our OAIC is: Translating Biological Mechanisms of Muscle Growth and Loss to Improve Function and Recovery in Older Adults. Our focus is on translating basic discoveries on the mechanisms of muscle loss and re-growth with aging to clinical practice to promote functional recovery and prevent disability in older adults. Observational studies will provide crucial information for selecting appropriate in-hospital, post-discharge, and long-term outcomes for inclusion in clinical trials of geriatric patient populations. Our general hypothesis is that aging induces mild but significant changes in muscle biology and function that progressively lead to muscle loss and predispose to potentially catastrophic declines in muscle mass and function during bouts of acute illness. We also hypothesize that anabolic interventions involving exercise/rehabilitation, amino acid/protein supplementation and hormonal or other pharmacological treatment can prevent the age- and disease-induced muscle loss and reduce the risk of

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG024832-09
Application #
8572265
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
9
Fiscal Year
2013
Total Cost
$206,084
Indirect Cost
$71,389
Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Graber, Ted G; Rawls, Brandy L; Tian, Bing et al. (2018) Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100
Chao, Tony; Porter, Craig; Herndon, David N et al. (2018) Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. Med Sci Sports Exerc 50:427-435
Li, Shuang; Middleton, Addie; Ottenbacher, Kenneth J et al. (2018) Trajectories Over the First Year of Long-Term Care Nursing Home Residence. J Am Med Dir Assoc 19:333-341
Lewis, Zakkoyya H; Markides, Kyriakos S; Ottenbacher, Kenneth J et al. (2018) The Impact of 10-Year Physical Activity Changes on 7-Year Mortality in Older Mexican Americans. J Phys Act Health 15:30-39
Deer, Rachel R; Goodlett, Shawn M; Fisher, Steve R et al. (2018) A Randomized Controlled Pilot Trial of Interventions to Improve Functional Recovery After Hospitalization in Older Adults: Feasibility and Adherence. J Gerontol A Biol Sci Med Sci 73:187-193
Krishnan, Shilpa; Pappadis, Monique R; Weller, Susan C et al. (2018) Patient-centered mobility outcome preferences according to individuals with stroke and caregivers: a qualitative analysis. Disabil Rehabil 40:1401-1409
Middleton, Addie; Graham, James E; Ottenbacher, Kenneth J (2018) Functional Status Is Associated With 30-Day Potentially Preventable Hospital Readmissions After Inpatient Rehabilitation Among Aged Medicare Fee-for-Service Beneficiaries. Arch Phys Med Rehabil 99:1067-1076
Díaz-Venegas, Carlos; Reistetter, Timothy A; Wong, Rebeca (2018) Differences in the Progression of Disability: A U.S.-Mexico Comparison. J Gerontol B Psychol Sci Soc Sci 73:913-922
Downer, Brian; Garcia, Marc A; Saenz, Joseph et al. (2018) The Role of Education in the Relationship Between Age of Migration to the United States and Risk of Cognitive Impairment Among Older Mexican Americans. Res Aging 40:411-431
Markofski, Melissa M; Jennings, Kristofer; Timmerman, Kyle L et al. (2018) Effect of Aerobic Exercise Training and Essential Amino Acid Supplementation for 24 Weeks on Physical Function, Body Composition and Muscle Metabolism in Healthy, Independent Older Adults: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci :

Showing the most recent 10 out of 408 publications