Abstract

The Research Development Core will promote the Shock Center's unifying objective ? to enhance and extend the Buck Institute's research program in the basic biology of aging ? by fostering the development of investigators and projects in aging research. This will be accomplished through the following activities: providing support for the career development of junior faculty in aging research; providing support for established investigators entering the aging field with new perspectives; designing and conducting training programs to prepare junior investigators for careers in aging research; identifying and supporting Pilot Projects with outstanding potential to advance knowledge of the basic biology of aging; organizing monthly Research Development Seminars given by external speakers and designed primarily to enhance the postdoctoral training experience; extending the expertise and core resources of the Buck Institute to other institutions and centers; and encouraging the entry of promising minority students and investigators into aging research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG025708-02
Application #
7309935
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$100,878
Indirect Cost

  Institution

Name
Buck Institute for Age Research
Department
Type
DUNS #
786502351
City
Novato
State
CA
Country
United States
Zip Code
94945

  Publications

Guyenet, Stephan J; Mookerjee, Shona S; Lin, Amy et al. (2015) Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction. Hum Mol Genet 24:3908-17
Chen, Di; Li, Patrick Wai-Lun; Goldstein, Benjamin A et al. (2013) Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep 5:1600-10
Flynn, James M; Melov, Simon (2013) SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radic Biol Med 62:4-12
Miller, John P; Yates, Bridget E; Al-Ramahi, Ismael et al. (2012) A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. PLoS Genet 8:e1003042
Flynn, James M; Czerwieniec, Gregg A; Choi, Sung W et al. (2012) Proteogenomics of synaptosomal mitochondrial oxidative stress. Free Radic Biol Med 53:1048-60
Goehring, Isabel; Gerencser, Akos A; Schmidt, Sara et al. (2012) Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics. J Biol Chem 287:15706-17
Katewa, Subhash D; Demontis, Fabio; Kolipinski, Marysia et al. (2012) Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab 16:97-103
Mookerjee, Shona A; Brand, Martin D (2011) Characteristics of the turnover of uncoupling protein 3 by the ubiquitin proteasome system in isolated mitochondria. Biochim Biophys Acta 1807:1474-81
Powolny, Anna A; Singh, Shivendra V; Melov, Simon et al. (2011) The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation. Exp Gerontol 46:441-52
Flynn, James M; Choi, Sung W; Day, Nicholas U et al. (2011) Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice. Free Radic Biol Med 50:866-73

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