The overall goal of the OAIC program is to increase scientific knowledge that will lead to effective ways to maintain or restore independence in older Americans. Innovative and appropriate analysis and data management methods are an important and necessary component to the scientific endeavor. A variety of designs, variables, hypotheses, and analyses will be explored, all with the common theme of 'Pathways to Disability'. An analysis core (AC) is proposed with 3 goals - (1) to provide an appropriate data management and analytic resources to the faculty, pilots, and projects in the Pepper Center, (2) to provide a resource in the measurement of physical performance, function, cognition, design and analysis so that appropriate measures will be employed using appropriately designed and analyzed experiments with appropriate conclusions, and (3) to develop innovative biostatistical analytic methodologies. To accomplish these goals, personnel with expertise and experience in data management, analysis, and measurement will direct activities in support ofthe overall Pepper. Both standard and innovative data management methods are proposed and employed, including standardization of analytic methods across studies and construction of data bases with common measures and variables. In addition to provision of technical analytic and data management support, the core will provide consultation, training and research support to the faculty ofthe Pepper Center. The core will also pursue methodologic goals of interest to statisticians and basic scientists. In particular, in order to develop valid and reproducible models ofthe relationship between biomarkers and function, several analytic considerations must be considered, including Type-1 error control for multiple testing, data aggregation, and measurement of change over time in several domains simultaneously. Working closely with the Biological Studies Core (RC2), we will focus on methods for examining trajectories of change in the biological and clinical expression of function, establish temporal ordering in these estimates, assessment of constancy of these relationships across studies, developing appropriate error structures for analysis given complex sampling schemes.

Public Health Relevance

The advancement of the scientific endeavor requires valid and appropriate data be measured and utilized, in appropriate designs, with appropriate analyses in order to test hypotheses and draw valid conclusions. If basic science questions relating function to biomarkers can be answered, then interventions which can raise the possibility of increasing functioning in older adults can be designed.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG028716-06
Application #
8205991
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (M1))
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$296,542
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Kanach, Frances A; Pastva, Amy M; Hall, Katherine S et al. (2018) Effects of Structured Exercise Interventions for Older Adults Hospitalized With Acute Medical Illness: A Systematic Review. J Aging Phys Act 26:284-303
Warsame, Fatima; Haugen, Christine E; Ying, Hao et al. (2018) Limited health literacy and adverse outcomes among kidney transplant candidates. Am J Transplant :
Longobardi, L; Jordan, J M; Shi, X A et al. (2018) Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 26:1257-1261
Garg, Tullika; Anzuoni, Kathryn; Landyn, Valentina et al. (2018) The AGING Initiative experience: a call for sustained support for team science networks. Health Res Policy Syst 16:41
Chou, C-H; Attarian, D E; Wisniewski, H-G et al. (2018) TSG-6 - a double-edged sword for osteoarthritis (OA). Osteoarthritis Cartilage 26:245-254
McAdams-DeMarco, Mara A; Olorundare, Israel O; Ying, Hao et al. (2018) Frailty and Postkidney Transplant Health-Related Quality of Life. Transplantation 102:291-299
Hall, Katherine S; Morey, Miriam C; Beckham, Jean C et al. (2018) The Warrior Wellness Study: A Randomized Controlled Exercise Trial for Older Veterans with PTSD. Transl J Am Coll Sports Med 3:43-51
Whitson, Heather E; Cohen, Harvey J; Schmader, Kenneth E et al. (2018) Physical Resilience: Not Simply the Opposite of Frailty. J Am Geriatr Soc 66:1459-1461
Morey, Miriam C; Lee, Cathy C; Castle, Steven et al. (2018) Should Structured Exercise Be Promoted As a Model of Care? Dissemination of the Department of Veterans Affairs Gerofit Program. J Am Geriatr Soc 66:1009-1016
Domingue, Benjamin W; Belsky, Daniel W; Fletcher, Jason M et al. (2018) The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health. Proc Natl Acad Sci U S A 115:702-707

Showing the most recent 10 out of 469 publications