The Duke Older Americans Independence Center (OAIC) is structured to (1) enhance and support research and (2) research career development In aging research through its Core resources. The central theme of our OAIC is to understand and modify the multiple pathways of functional decline. The OAIC is based in the Duke Center for the Study of Aging and Human Development, an all-university program with strong multidisciplinary affiliated programs such as the Durham VA GRECC, the Hartford Center of Excellence, the Duke Institute for Genomic Sciences and Policy, the Duke Translational Medicine Institute, the Duke Center for Living, and the Stedman Nutrition and Metabolism Center. This rich milieu includes 130 faculty as Senior Fellows of the Aging Center and over 25 million dollars of research germane to the goals of the OAIC. The Duke OAIC will support three resource cores which have evolved from prior OAIC support: (1) an Analysis Core, (2) a Biochemical Pathways Core, and a (3) Metabolomics Core. Several externally funded NIH, VA or industry-sponsored grants, with relevant study aims and study populations will receive support from these cores.
New specific aims relevant to our Center theme will be added for each external project. Data from these studies (interventional and cohort) will be added to a common database that includes data from our prior funding periods. This extends our research capabilities and allows us to develop new ideas for investigation. The Research Career Development Core and the Pilot/Exploratory Studies Core will facilitate career development and enhancement of research capabilities with established post-doctoral Research and Geriatric Training Programs and participation in the Duke OAIC Research Seminar Series, the Data Integration Working Group, the Pilot Studies workshop, the Pepper Scholars program, and access as needed to a Functional Measurement Resource group. The cores are seamlessly integrated and work closely to develop young trainees and research projects by interactions from concept through completion of proposed work. During the first year, three pilot projects, two development projects, and three junior faculty will be supported. Subsequent support for career development, pilot projects, and development will be selected on a competitive basis using criteria clearly defined in the OAIC guidelines. A Leadership and Administrative Core will direct and coordinate OAIC activities to ensure continued integration of center activities.

Public Health Relevance

The public impact will be a significant advancement in the basic understanding of the multiple factors that contribute to functional decline, and the enhancement of interventions directed at improving the overall quality of life of older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
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Eldadah, Basil A
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Duke University
Internal Medicine/Medicine
Schools of Medicine
United States
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Devinney, Michael J; Mathew, Joseph P; Berger, Miles (2018) Postoperative Delirium and Postoperative Cognitive Dysfunction: Two Sides of the Same Coin? Anesthesiology 129:389-391
Hall, Rasheeda K; Sloane, Richard; Pieper, Carl et al. (2018) Competing Risks of Fracture and Death in Older Adults with Chronic Kidney Disease. J Am Geriatr Soc 66:532-538
Duan-Porter, Wei; Hatch, Daniel; Pendergast, Jane F et al. (2018) 12-month trajectories of depressive symptoms among nurses-Contribution of personality, job characteristics, coping, and burnout. J Affect Disord 234:67-73
Cary Jr, Michael P; Hall, Rasheeda K; Anderson, Amber L et al. (2018) Management Team Perceptions of Risks and Strategies for Preventing Falls Among Short-Stay Patients in Nursing Homes. Health Care Manag (Frederick) 37:76-85
Hall, Rasheeda K; McAdams-DeMarco, Mara A (2018) Breaking the cycle of functional decline in older dialysis patients. Semin Dial 31:462-467
Pavon, Juliessa M; Sloane, Richard J; Pieper, Carl F et al. (2018) Automated versus Manual Data Extraction of the Padua Prediction Score for Venous Thromboembolism Risk in Hospitalized Older Adults. Appl Clin Inform 9:743-751
Allen, Jason D; Vanbruggen, Mitch D; Johannsen, Neil M et al. (2018) PRIME: A Novel Low-Mass, High-Repetition Approach to Improve Function in Older Adults. Med Sci Sports Exerc 50:1005-1014
Lee, Richard H; Sloane, Richard; Pieper, Carl et al. (2018) Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications. J Clin Endocrinol Metab 103:281-287
Pastva, Amy M; Duncan, Pamela W; Reeves, Gordon R et al. (2018) Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial. Contemp Clin Trials 64:118-127
White, James P; Billin, Andrew N; Campbell, Milton E et al. (2018) The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells. Stem Cell Reports 11:425-439

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