The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons' physical performance and mobility through interdisciplinary approaches; and 2) to train new investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus: ?mobility and prevention of disability.? Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, and engineering, our research effort addresses the OAIC's general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using translational research (among diverse disciplines), the biological, co-morbid, psychosocial, behavioral, and other factors that contribute to physical function decline, loss of mobility, and progression toward disability; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Junior Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: ? Leadership and Administrative Core; ? Research Education Core; ? Pilot/Exploratory Studies Core; ? Clinical Research Core; ? Metabolism and Translational Science Core; ? Biostatistics Core; and ? Data Science and Applied Technology Core. A relevant strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.
Better knowledge of the factors leading to optimizing mobility and developing efficacious and effective interventions to avert disability will have a major impact on practicing evidence-based geriatric medicine and public health.
Loftus, Tyler J; Kannan, Kolenkode B; Carter, Christy S et al. (2018) Persistent injury-associated anemia and aging: Novel insights. J Trauma Acute Care Surg 84:490-496 |
Miller, Michael E; Magaziner, Jay; Marsh, Anthony P et al. (2018) Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations. J Am Geriatr Soc 66:954-961 |
Hawkins, Russell B; Raymond, Steven L; Stortz, Julie A et al. (2018) Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome. Front Immunol 9:1511 |
Côté, Isabelle; Sakarya, Yasemin; Green, Sara M et al. (2018) iBAT sympathetic innervation is not required for body weight loss induced by central leptin delivery. Am J Physiol Endocrinol Metab 314:E224-E231 |
Trombetti, Andrea; Hars, Mélany; Hsu, Fang-Chi et al. (2018) Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med 168:309-316 |
Picca, Anna; Lezza, Angela Maria Serena; Leeuwenburgh, Christiaan et al. (2018) Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders. Rejuvenation Res 21:350-359 |
Nickerson, Paul V; Baharloo, Raheleh; Wanigatunga, Amal A et al. (2018) Transition Icons for Time-Series Visualization and Exploratory Analysis. IEEE J Biomed Health Inform 22:623-630 |
Cunningham, Holly B; Scielzo, Shannon A; Nakonezny, Paul A et al. (2018) Burn Surgeon and Palliative Care Physician Attitudes Regarding Goals of Care Delineation for Burned Geriatric Patients. J Burn Care Res 39:1000-1005 |
Hernandez, Abbi R; Hernandez, Caesar M; Campos, Keila T et al. (2018) The Antiepileptic Ketogenic Diet Alters Hippocampal Transporter Levels and Reduces Adiposity in Aged Rats. J Gerontol A Biol Sci Med Sci 73:450-458 |
Strickland, Michael R; Koller, Emily J; Deng, Doris Z et al. (2018) Ifngr1 and Stat1 mediated canonical Ifn-? signaling drives nigrostriatal degeneration. Neurobiol Dis 110:133-141 |
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