The Biostatistics Core (RC3) is one of the four resource cores in the Claude D. Pepper Older Americans Independence Center (OAIC) at the University of Florida (UF). The mission of the UF OAIC is twofold: 1) to enhance late-life health and independence through interdisciplinary approaches to optimize physical performance and mobility, and 2) to train new investigators in research on aging and disability, while developing their leadership qualities. The RC3 is a key cog in the interaction among scientists from diverse disciplines to accomplish this mission. It provides research-design and statistical-analysis resources and helps construct data-collection forms and manage the data (including providing quality control) for both preclinical and clinical studies conducted within the OAIC. The RC3 is involved in all phases of the OAIC studies: initial pre-proposal study design and sample-size calculations, randomization, and state-of-the-art statistical analyses once the data are collected. It also helps prepare manuscripts for dissemination within the research community. In addition, the RC3 serves as a key resource to OAIC junior faculty and Junior Scholars, providing consulting services and periodic special-interest training topics, such as research design, power analysis, data management, study implementation and management, and statistical methodology and analyses. Finally, for OAIC studies where the existing biostatistical methodologies are inadequate, the RC3 has assembled strong expertise for developing new biostatistical methods and data-management tools beyond current practice. The RC3 will develop new methodology for adaptive design of clinical trials and simultaneous statistical inference. This will provide customized support that meets the demands of the OAIC's research design and statistical analyses.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028740-13
Application #
9690526
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
13
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Florida
Department
Type
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Brakenridge, Scott C; Efron, Philip A; Stortz, Julie A et al. (2018) The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients. J Trauma Acute Care Surg 85:247-255
Shenkman, Elizabeth; Hurt, Myra; Hogan, William et al. (2018) OneFlorida Clinical Research Consortium: Linking a Clinical and Translational Science Institute With a Community-Based Distributive Medical Education Model. Acad Med 93:451-455
Hernandez, Abbi R; Hernandez, Caesar M; Campos, Keila et al. (2018) A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus. Front Aging Neurosci 10:391
Liu, Xinyue; Carney, Paul R; Bussing, Regina et al. (2018) Stimulants Do Not Increase the Risk of Seizure-Related Hospitalizations in Children with Epilepsy. J Child Adolesc Psychopharmacol 28:111-116
Dahodwala, Nabila; Shah, Krunal; He, Ying et al. (2018) Sex disparities in access to caregiving in Parkinson disease. Neurology 90:e48-e54
Buford, Thomas W; Manini, Todd M; Kairalla, John A et al. (2018) Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc 7:e010009
Chen, Haiying; Rejeski, W Jack; Gill, Thomas M et al. (2018) A Comparison of Self-report Indices of Major Mobility Disability to Failure on the 400-m Walk Test: The LIFE Study. J Gerontol A Biol Sci Med Sci 73:513-518
Bihorac, Azra; Ozrazgat-Baslanti, Tezcan; Ebadi, Ashkan et al. (2018) MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery. Ann Surg :
Rillamas-Sun, Eileen; LaMonte, Michael J; Evenson, Kelly R et al. (2018) The Influence of Physical Activity and Sedentary Behavior on Living to Age 85 Years Without Disease and Disability in Older Women. J Gerontol A Biol Sci Med Sci 73:1525-1531
Moore, Brenda D; Martin, Jason; de Mena, Lorena et al. (2018) Short A? peptides attenuate A?42 toxicity in vivo. J Exp Med 215:283-301

Showing the most recent 10 out of 1197 publications