Most older adults will develop one or more chronic illnesses with which they may live for years, often with symptom distress and progressive functional dependence. There is now abundant evidence that the quality of life during these advanced stages of disease is poor. The goal of this OAIC is to establish a research program focused on the relationship of pain and other symptoms to independence and function in older people with serious illness. The OAIC is built from a foundation of grants totaling $34.4 million started by the Center's principals in the late 1990s. These grants have spawned an additional 42 grants totaling $18.8 million supporting research, career development, and infrastructure. In this proposal, we expand this research foundation through strengthened collaborations with colleagues in Psychiatry, Medicine, Orthopedics and at the Hebrew Home for the Aged, among others. These collaborations are the source for new research projects and junior faculty with interests in geriatrics and palliative care. Three of the OAIC cores will be led by individuals who have devoted their careers to geriatrics, a fourth is led by an expert in clinical trials methods who is CAQ'ed in geriatrics, and the fifth is led by a senior gerontologist. The OAIC will recruit and train academic leaders, and it will support pilot and exploratory studies. It will also establish 2 research cores (research design and analysis, measurement and data management) that will apply innovative methods not currently in widespread use in aging research but that are highly applicable to aging. The Center will bring together a) leadership by senior geriatricians who are long-standing colleagues with a shared track record of successful research and training program building;b) senior faculty with a substantial body of research contributions;and c) promising junior investigators. Our Center's theme has its roots in the deepest traditions of medicine: attention to the primacy of the relief of suffering. Ancient though this priority may be, medical research in general, and geriatric research in particular, are poised to bring modern techniques and knowledge to what is in fact a new area of focus for the OAIC program - the effective amelioration of pain and other symptoms to improve function and promote independence in older adults. The proposed Center will bridge geriatrics and palliative care and serve as a model for a new focused area of research within geriatrics.

Public Health Relevance

Substantial data suggest that the care of older adults living with serious illness is in need of improvement. The proposed OAIC would establish a sustainable infrastructure to support the development of new investigators in geriatric palliative care research, support research in geriatric palliative care, and develop or adapt instruments, designs, and analytic methods necessary to improve care for seriously ill older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (A1))
Program Officer
Eldadah, Basil A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Icahn School of Medicine at Mount Sinai
Internal Medicine/Medicine
Schools of Medicine
New York
United States
Zip Code
Chang, Sanders; Ru, Meng; Moshier, Erin L et al. (2018) The impact of radiation treatment planning technique on unplanned hospital admissions. Adv Radiat Oncol 3:647-654
Gelfman, Laura P; BarrĂ³n, Yolanda; Moore, Stanley et al. (2018) Predictors of Hospice Enrollment for Patients With Advanced Heart Failure and Effects on Health Care Use. JACC Heart Fail 6:780-789
Ko, Fred C; Rubenstein, William J; Lee, Eric J et al. (2018) TNF-? and sTNF-RII Are Associated with Pain Following Hip Fracture Surgery in Older Adults. Pain Med 19:169-177
Hua, May; Ma, Xiaoyue; Morrison, R Sean et al. (2018) Association between the Availability of Hospital-based Palliative Care and Treatment Intensity for Critically Ill Patients. Ann Am Thorac Soc 15:1067-1074
Song, Wei; Intrator, Orna; Lee, Sei et al. (2018) Antihypertensive Drug Deintensification and Recurrent Falls in Long-Term Care. Health Serv Res 53:4066-4086
Chang, Sanders; May, Peter; Goldstein, Nathan E et al. (2018) A Palliative Radiation Oncology Consult Service Reduces Total Costs During Hospitalization. J Pain Symptom Manage 55:1452-1458
Chang, Sanders; May, Peter; Goldstein, Nathan E et al. (2018) A Palliative Radiation Oncology Consult Service's Impact on Care of Advanced Cancer Patients. J Palliat Med 21:438-444
Dharmarajan, Kavita V; Rich, Shayna E; Johnstone, Candice A et al. (2018) Top 10 Tips Palliative Care Clinicians Should Know About Radiation Oncology. J Palliat Med 21:383-388
Hays, Ron D; Weech-Maldonado, Robert; Teresi, Jeanne A et al. (2018) Commentary: Copyright Restrictions Versus Open Access to Survey Instruments. Med Care 56:107-110
Chun, Audrey; Reinhardt, Joann P; Ramirez, Mildred et al. (2017) Depression recognition and capacity for self-report among ethnically diverse nursing homes residents: Evidence of disparities in screening. J Clin Nurs 26:4915-4926

Showing the most recent 10 out of 95 publications