Established in 1991, the UCLA Claude D. Pepper Older Americans Independence Center (UCLA OAIC) seeks a third renewal to continue its mission of expanding the scientific knowledge that will lead to better ways to maintain or restore independence. In this renewal, we will focus our efforts on the theme, """"""""Developing Interventions to Maintain Independence and Understanding Mechanisms of Successful Interventions,"""""""" which extends the Center's prior research. Thus, the emphasis will be on research that builds bridges between basic biomedical science and clinical science. In the UCLA OAIC paradigm, basic biomedical research informs clinical research and clinical research informs basic biomedical research. Accordingly, the UCLA OAIC will support research that links these two types of research in both directions by 1) examining mechanisms underlying successful clinical interventions and 2) developing new basic science approaches that will lead to clinical interventions. The Center will stimulate scientific discovery through 4 Research Cores (Recruitment, Research Operations, Analysis and Cost-effectiveness, and Inflammatory Biology), a Pilot and Exploratory Studies (P/EC) Core, and Research Career Development Core (RCDC). Research Cores will provide 4 levels of support (consultation, short-term, ongoing, and partnership on new projects) for external projects (e.g., R01s) and internal OAIC activities (e.g., pilots and Career Development Awardees). The UCLA OAIC will accomplish its goals by accomplishing 6 Specific Aims: 1) To provide intellectual leadership and innovation for geriatrics and aging research on the Center's theme and related research 2) To stimulate translational links between basic and clinical research, with an emphasis on inflammation 3) To facilitate and develop novel multidisciplinary research 4) To stimulate incorporation of emerging technologies 5) To serve as source of advice and collaboration to other institutions 6) To provide career development of future research leaders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028748-04
Application #
7643175
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (M1))
Program Officer
Hadley, Evan
Project Start
2006-09-15
Project End
2011-06-30
Budget Start
2009-08-01
Budget End
2010-06-30
Support Year
4
Fiscal Year
2009
Total Cost
$1,089,159
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kim, Seungyoun; Spilman, Samantha L; Liao, Diana H et al. (2018) Social networks and alcohol use among older adults: a comparison with middle-aged adults. Aging Ment Health 22:550-557
Goldwater, Deena; Karlamangla, Arun; Merkin, Sharon Stein et al. (2018) Interleukin-10 as a predictor of major adverse cardiovascular events in a racially and ethnically diverse population: Multi-Ethnic Study of Atherosclerosis. Ann Epidemiol :
Kuerbis, Alexis; Reid, M Carrington; Lake, Jordan E et al. (2018) Daily Factors Driving Daily Substance Use and Chronic Pain among Older Adults with HIV: An Exploratory Study Using Ecological Momentary Assessment. Alcohol :
Majeno, Angelina; Tsai, Kim M; Huynh, Virginia W et al. (2018) Discrimination and Sleep Difficulties during Adolescence: The Mediating Roles of Loneliness and Perceived Stress. J Youth Adolesc 47:135-147
Zonis, Svetlana; Breunig, Joshua J; Mamelak, Adam et al. (2018) Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. J Neuroinflammation 15:260
Tsai, Kim M; Dahl, Ronald E; Irwin, Michael R et al. (2018) The Roles of Parental Support and Family Stress in Adolescent Sleep. Child Dev 89:1577-1588
Hernandez, Rosalba; Cheung, Elaine; Liao, Minli et al. (2018) The Association Between Depressive Symptoms and Cognitive Functioning in Older Hispanic/Latino Adults Enrolled in an Exercise Intervention: Results From the ""¡Caminemos!"" Study. J Aging Health 30:843-862
Chiang, Jessica J; Ko, Ahra; Bower, Julienne E et al. (2018) Stress, Psychological Resources, and HPA and Inflammatory Reactivity During Late Adolescence. Dev Psychopathol :1-14
Lê-Scherban, Félice; Brenner, Allison B; Hicken, Margaret T et al. (2018) Child and Adult Socioeconomic Status and the Cortisol Response to Acute Stress: Evidence From the Multi-Ethnic Study of Atherosclerosis. Psychosom Med 80:184-192
Hsu, Jeffrey J; Lu, Jinxiu; Umar, Soban et al. (2018) Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol 314:H1203-H1213

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