Although the prevalence of chronic disability in older individuals remains on the decline in the United States, the total number of individuals over the age of 65 with chronic disability is increasing (1, 2). Presently, limitations in mobility affect almost one in four individuals over age 65 and three quarters of those living in nursing homes (3). In non-disabled older individuals, limitations in mobility in such tasks as climbing stairs, and walking across a room have been defined as 'mobility disability' (4). To capture and assess mobility limitations in the elderly, performance tests of functional capacity have been developed and have been shown to be predictive of incident disability, institutionalization, and mortality (4, 5). In particular, walking ability alone, as measured by gait speed during a 4 M walk test, has been shown to be a strong predictor of subsequent ADL disability and mobility disability (6). In addition, validated highly reliable instruments to assess components of physical disability have also been developed and implemented in observational studies and clinical trials. More recently, testing protocols in selected animal models (rats, mice) have been developed to assess important endpoints related to impairments and functional limitations in these species.

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National Institute on Aging (NIA)
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Boston Medical Center
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Miller, Michael E; Magaziner, Jay; Marsh, Anthony P et al. (2018) Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations. J Am Geriatr Soc 66:954-961
Trombetti, Andrea; Hars, Mélany; Hsu, Fang-Chi et al. (2018) Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med 168:309-316
Wanigatunga, Amal A; Manini, Todd M; Cook, Delilah R et al. (2018) Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults. Front Aging Neurosci 10:341
Gagliano-Jucá, T; Storer, T W; Pencina, K M et al. (2018) Testosterone does not affect agrin cleavage in mobility-limited older men despite improvement in physical function. Andrology 6:29-36
Callahan, Kathryn E; Lovato, Laura; Miller, Michael E et al. (2018) Self-Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc 66:1927-1933
Huang, Grace; Pencina, Karol M; Li, Zhuoying et al. (2018) Long-Term Testosterone Administration on Insulin Sensitivity in Older Men With Low or Low-Normal Testosterone Levels. J Clin Endocrinol Metab 103:1678-1685
Liu, Zuyun; Hsu, Fang-Chi; Trombetti, Andrea et al. (2018) Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial. BMC Med 16:185
von Berens, Åsa; Fielding, Roger A; Gustafsson, Thomas et al. (2018) Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trial. BMC Geriatr 18:286
Sipilä, Sarianna; Tirkkonen, Anna; Hänninen, Tuomo et al. (2018) Promoting safe walking among older people: the effects of a physical and cognitive training intervention vs. physical training alone on mobility and falls among older community-dwelling men and women (the PASSWORD study): design and methods of a randomize BMC Geriatr 18:215
Buford, Thomas W; Manini, Todd M; Kairalla, John A et al. (2018) Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc 7:e010009

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