Functional decline and dependence in older individuals portend poor outcome, and impose a large burden on health care services and costs. Therefore, function promoting anabolic therapies (FPATs) that improve physical function and reduce the burden of disabling functional limitations are desirable. The Boston Claude A. Pepper Older Americans Independence Center (OAIC) with its thematic focus on functional limitations and FPATs will integrate 13 NIH-funded studies, 4 innovative pilot projects, and 2 developmental projects into a cohesive interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Career Development Core (RCDC), a Pilot and Exploratory StudieSxCore, and three resource cores (Function Assessment Core, Muscle Progenitor Cell Core, and Systems Biology Core). The Boston OAIC is unique in its positioning across the entire spectrum of translational discovery research: 13 OAIC projects, and pilot and developmental projects will elucidate the epidemiology of functional limitations and mechanisms of FPAT action, help identify targets for FPAT discovery and biomarkers of FPAT action, and facilitate methods development, outcomes validation, and efficacy trials of leading FPATs. The RCDC will recruit the best candidates from several disciplines, induing Geriatrics and Gerontology, and train them through a structured didactic education and mentored research program. Integration across OAIC will be achieved by weekly interdisciplinary research meetings, biannual retreats, a website, common thematic focus, and the PROMOTE program aimed at promoting collaboration. Community outreach and dissemination of OAIC activities will be achieved through Ambassador's Program which will organize community events, a newsletter, and a Community Advisory Board. Unique strengths of OAIC include its focus on FPATs, emphasis on innovation, its extension across entire spectrum of translational research from mechanism elucidation to efficacy trials, a history of productive collaborations among its members, strong infrastructure and institutional commitment, and inclusion of several important epidemiologic investigations (FHS, MMAS, BACH, Centenarian Study, and BOKS), FPAT intervention trials, and mechanism-based FPAT discoveries. Boston OAlC's collaborative strategies should help expedite the translation of research results into evidence-based FPATs and nurture a new generation of aging researchers. PROGRAM AS A WHOLE

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG031679-05
Application #
8301627
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Program Officer
Eldadah, Basil A
Project Start
2008-09-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
5
Fiscal Year
2012
Total Cost
$1,094,232
Indirect Cost
$218,657
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Tapper, J; Arver, S; Pencina, K M et al. (2018) Muscles of the trunk and pelvis are responsive to testosterone administration: data from testosterone dose-response study in young healthy men. Andrology 6:64-73
Tran, Thanh; Guardigni, Viola; Pencina, Karol M et al. (2018) Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults. Clin Infect Dis 66:1918-1927
Orkaby, Ariela R; Rich, Michael W; Sun, Ryan et al. (2018) Pravastatin for Primary Prevention in Older Adults: Restricted Mean Survival Time Analysis. J Am Geriatr Soc 66:1987-1991
Kim, Dae Hyun; Mahesri, Mufaddal; Bateman, Brian T et al. (2018) Longitudinal Trends and Variation in Antipsychotic Use in Older Adults After Cardiac Surgery. J Am Geriatr Soc 66:1491-1498
Bhasin, S; Travison, T G; O'Brien, L et al. (2018) Contributors to the substantial variation in on-treatment testosterone levels in men receiving transdermal testosterone gels in randomized trials. Andrology 6:151-157
Margolis, Lee M; Rivas, Donato A (2018) Potential Role of MicroRNA in the Anabolic Capacity of Skeletal Muscle With Aging. Exerc Sport Sci Rev 46:86-91
Wasson, Emily; Rosso, Andrea L; Santanasto, Adam J et al. (2018) Neural correlates of perceived physical and mental fatigability in older adults: A pilot study. Exp Gerontol 115:139-147
Jang, Il-Young; Jung, Hee-Won; Park, Hyelim et al. (2018) A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study. Clin Interv Aging 13:1799-1814
Kim, Dae Hyun (2018) Incorporating Quality of Life Prediction in Shared Decision Making About Transcatheter Aortic Valve Replacement. Circ Cardiovasc Qual Outcomes 11:e005097
Dagan, Moria; Herman, Talia; Harrison, Rachel et al. (2018) Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease. Mov Disord 33:642-646

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